Project Grant RF1NS128901

Award Date 8/15/22
Completion Date 7/31/25
Dollars Obligated $4.5M
Federal Grant Program
93.372
Assistance Type
Project Grant
Place of Performance
Texas, USA
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The grant aims to advance understanding of how the neuromodulators acetylcholine and norepinephrine shape cortical responses and influence behavior. Researchers will study the spatial and temporal dynamics of neuromodulator availability in mouse sensory cortex using new methods to simultaneously record neural population activity and local neuromodulator levels. They will test how neuromodulator inhomogeneities impact neural signatures of the activated cortical state. Additionally, $114,019 in subaward funding was provided to Princeton University to develop computational analysis frameworks relating behavioral state changes, neuromodulation, and neural population activity recorded through the project. Insights gained from this research could help identify subtle changes in neuromodulator effects associated with various disease states.

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