Project Grant RF1NS127413
- The National Institute on Aging awarded $3,391,684 under the Aging Research grant program (CFDA 93.866) to Texas A&M University Health Science Center from May 1, 2022 to April 30, 2025. The project aims to test the hypothesis that peripheral insulin-like growth factor-1 (IGF-1), delivered intraperitoneally or orally, will improve acute stroke disability as well as chronic depressive-like behaviors and cognitive impairment post-stroke in a rodent model. Researchers also expect peripheral...
- This $399,345 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate novel therapeutic strategies for improving outcomes of acute ischemic stroke (AIS) in older mice. The key research objectives are to: (1) Rejuvenate age-associated reductions in endothelial cell (EC) autophagy and restore EC glucose transporter 1 (GLUT1) expression to improve EC function and AIS outcomes; and (2) Evaluate whether the approved drug bryostatin-1 can...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
- The National Institute on Aging (NIA) awarded a Project Grant totaling $173,730 to the University of Washington under the Aging Research federal grant program (CFDA 93.866) beginning on September 1, 2025. The goal of this Midcareer Investigator Award in Patient-Oriented Research is to enhance the ability of Dr. Claire Creutzfeldt to train, mentor, and support the career development of clinician-scientists focused on developing and testing interventions to improve the quality of life, quality...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $1,083,046 Project Grant under the Aging Research program (CFDA 93.866) to The Johns Hopkins University. The grant, running from August 1, 2025 to July 31, 2027, will support the development of novel adeno-associated viruses (AAVs) to selectively manipulate oligodendrocyte precursor cells (OPCs) in the central nervous system. The project aims to test the hypothesis that reactive...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $429,000 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Oregon Health & Science University (OHSU). The purpose of this 2-year grant is to investigate mechanisms of white matter injury following an ischemic stroke and evaluate the neuroprotective effects of the CK2 inhibitor CX-4945 on preserving white matter function. The project aims to utilize...
- The National Institute on Aging awarded a $1,931,965 Project Grant (CFDA 93.866 - Aging Research) to the Regenerative Research Foundation, a non-profit organization in Albany, New York. The purpose of this federal grant is to develop and validate a novel human induced pluripotent stem cell (iPSC) model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, and microglia to study cerebrovascular interactions in Alzheimer's disease-related dementias (ADRD). The R61 phase of...
- This $4.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The University of Michigan will examine racial inequities in neurological conditions like vascular contributions to cognitive impairment and dementia (VCID) and stroke. Leveraging the Reasons for Geographic and Racial Differences in Stroke study cohort of over 30,000 adults, the research aims to determine...
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,685 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). The funding will support the development of an injectable hydrogel with an integrated urokinase plasminogen activator (uPA) motif and plasmid DNA (pDNA) platelet-derived growth factor B (PDGFB)-lipoplexes to be loaded into the...
- This $146,922 Project Grant awarded by the National Institute on Aging (Aging Research, CFDA 93.866) will fund a study to evaluate the relationship between life-space - the size and pattern of the physical area individuals spend their time in - and long-term cognitive decline after stroke. The study aims to: (1) estimate the effects of life-space components on cognitive decline in the years following stroke in a large observational cohort, (2) characterize the life-space of stroke survivors...
The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,387,438 under the Aging Research program (CFDA 93.866) to The Ohio State University Office of Sponsored Programs on September 19, 2022. The three-year project grant aims to develop and test a novel neuroprotective agent, TAT-M2NX, to provide both acute and sustained synaptic protection following acute ischemic stroke. The research seeks to characterize the agent's dosing regimen and assess its ability to enhance long-term cognitive recovery in a rodent model, moving beyond traditional outcome measures to also evaluate cognitive effects. By investigating the interactions between acute injury, delayed neuronal cell death, and conversion to chronic dysfunction, the project aims to establish TAT-M2NX as an adjunct therapy to reperfusion techniques like endovascular thrombectomy, with the goal of meaningfully improving quality of life outcomes for stroke patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.7m | 9/20/22 | ||
| Not listed | $1.7m | 9/20/22 |