Project Grant RF1MH141903
- This Project Grant award in the amount of $774,632 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The funding supports research to investigate how changes in dopamine signaling in the brain's dorsal striatum region can disrupt spatial working memory and auditory perception, which are relevant to understanding dopamine-associated neuropsychiatric diseases such as schizophrenia. The research utilizes in vivo imaging...
- This federal Project Grant award of $742,484 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will fund a comprehensive research initiative to characterize a genetic mouse model and delineate its function in the brain. The project aims to obtain multiome single nucleus RNA-sequencing and ATAC-seq data, analyze and correlate the data sets, and examine chromatin state and brain morphology changes. Additionally, the project will...
- This $484,546 federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants program) supports research by Northwestern University to investigate the neural circuit computations underlying foraging behavior in mice. The project aims to develop a new mouse foraging task and use it to test a model of how the basal ganglia encode information about the costs and benefits associated with different foraging options to guide decision-making....
- This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the role of cortico-striatal circuitry in model-based decision-making. The $189,540 grant, awarded on February 1, 2025, will be used to monitor and manipulate neural activity in the prelimbic cortex and dorsomedial striatum to determine how model-based control, a key decision-making process, is represented in distinct cell types...
- This Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) provides $732,635.00 to The University of Iowa to investigate the role of the mediodorsal thalamus in encoding and updating context representations critical for human cognitive flexibility. The research aims to use computational models, 7T MRI, and advanced neuroimaging analyses to better understand the neural mechanisms underlying context processing and its deficits in psychiatric...
- The National Institute of Mental Health (NIMH) awarded a $2,515,724 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Regents of the University of Michigan to further develop NTracer2, a cloud-based platform for brain image visualization and neuron tracing. The project aims to establish NTracer2's SISF data framework as a scalable image data standard, continue developing the NTracer2 content delivery network and application server, and deploy the full-stack...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), provides $120,015.00 to President and Fellows of Harvard College to develop a novel technological pipeline that enables monitoring of large-scale neural activity in freely moving animals and identifies the transcriptomic identity of individual neurons. The project aims to achieve a comprehensive understanding of how sensory information integrates...
- The federal Project Grant award of $119,742 from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) supports research on the "Molecular and Functional Implications of Thalamo-Striatal Synapse Regulation in Learning and Memory." The award was made to the Regents of the University of Minnesota and covers the project period from November 1, 2024 to July 31, 2026. The research focuses on understanding the mechanisms behind age-related declines in...
- The National Institute of Mental Health (NIMH) awarded a $725,422 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the Massachusetts Institute of Technology (MIT) on May 1, 2025. The grant supports research investigating the role of striatal astrocytes and striosomes in modulating dopamine signals and facilitating behavioral state transitions in the basal ganglia circuitry. The research aims to determine whether astrocyte activity causally affects learning,...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding the development of a "Scalable High-Plex Pipeline for Whole-Brain Proteomics Profiling". The $1,988,947 award aims to create a scalable proteomics profiling system that can comprehensively map the molecular signatures of distinct brain cell types in the human brain. The project involves increasing the multiplexing capability to...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $2,908,921 to study the role of midbrain signals in differential reinforcement learning. The University of Michigan is conducting research to understand how the inferior colliculus, a key midbrain structure, contributes to auditory associative learning and plasticity. Using 2-photon calcium imaging in behaving mice, the researchers aim to investigate how inferior colliculus neuron activity predicts behavioral choices and responds to reinforcing outcomes, which may provide insights into the neural mechanisms underlying learning and memory. This 4-year project, awarded on September 22, 2025, seeks to advance scientific understanding of the brain processes underlying cognition and associative learning.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.9m | 9/22/25 |