This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
The National Institute of Mental Health (NIMH) awarded a $11,731,574 Cooperative Agreement under the Mental Health Research Grants program (CFDA 93.242) to the Massachusetts Institute of Technology (MIT) to create comprehensive 3D brain atlases for humans and non-human primates. The goal is to simultaneously map brain-wide function, structure, and high-dimensional features (e.g., proteomic, transcriptomic, spatial, morphological, microenvironment, and nanoscopic information) of cells acquired...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....
The National Institute of Mental Health (NIMH) awarded a $10,960,536 Cooperative Agreement under the Mental Health Research Grants (CFDA 93.242) program to the Regents of the University of Michigan. The project, titled "COMPASS: A Comprehensive Mobile Precision Approach for Scalable Solutions in Mental Health Treatment", aims to develop predictive models that optimize mental health treatments by leveraging mobile technology and machine learning. The 5-year project will recruit 4,400...
The University of South Carolina (USC) was awarded a $2,039,629 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The 3-year grant, which began on August 1, 2023, will support the development and refinement of software tools to visualize and analyze data collected through the Brain Initiative. Key activities include: Extending the EZBids software to ease the creation of shared data, improve intention prediction,...
This Project Grant award of $443,931 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to demonstrate accurate quantification of changes in brain morphology using a portable 0.05T magnetic resonance imaging (MRI) scanner. The study plans to acquire densely sampled neuroimaging data over multiple time points, coupled with autonomous control and deep-learning-based super-resolution reconstruction, to yield early, accurate, and...
The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Intelligent Imaging Innovations, Inc. (3i) to develop a commercial instrument for large-scale, all-optical electrophysiology. The goal is to combine advanced optical techniques, including volumetric neural activity imaging and computer-generated holography, to enable simultaneous optical recording and manipulation of neuron activity across multiple brain regions. The...
The National Institute of Mental Health (NIMH) awarded a $446,490 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Esperimage LLC, a startup company based in Missouri. The funding will support the development of efficient and flexible data registration and modeling procedures to complement Esperimage's high-fidelity, wearable optical technology for naturalistic brain imaging in adults and children. The goal is to enable better understanding of disease mechanisms and monitoring of...
The National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), awarded a $600,000 Project Grant to The University of Texas Southwestern Medical Center in Dallas, TX. The funding will be used to purchase a TissueVision TissueCyte 1600FC Serial Two-Photon Tomography (STPT) microscope system. This advanced imaging system will enable high-throughput, high-resolution automated imaging of whole, uncleared rodent brains or spinal cord segments for...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...