This federal Project Grant award from the National Institute of Mental Health (NIMH) under the 93.242 Mental Health Research Grants program provides $446,490 to Esperimage LLC, a startup company out of Washington University, to develop efficient and flexible data registration and modeling procedures for their high-fidelity, wearable optical brain imaging technology. The goal is to enable naturalistic brain imaging in adults and children, especially those with autism spectrum disorder (ASD), to advance early detection and treatment of neurodevelopmental disorders. The project will validate the registration and modeling methods in healthy adults and autistic/non-autistic children to establish feasibility for commercialization of the wearable high-density diffuse optical tomography (WHD-DOT) system in a future Phase II effort. This funding will help overcome limitations of current brain imaging techniques and provide an essential data registration and modeling product to support the commercialization of Esperimage's innovative optical neuroimaging technology.