Project Grant RF1AG096495
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $4.59 million under the Aging Research program (CFDA 93.866) to develop and validate automated speech analysis technology for early detection of Alzheimer's disease (AD). The award, obligated on September 5, 2025, with a completion date of August 31, 2029, supports a multidisciplinary research initiative that leverages machine learning algorithms to...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $6.9 million Project Grant under the Aging Research program (CFDA 93.866) to develop a Multi-Organ AI-Derived Endophenotype (MAE) framework for personalized assessment of Alzheimer's disease and related dementia susceptibility. The grant, effective August 1, 2025 through July 31, 2029, supports the creation of computational diagnostic and prognostic tools by consolidating and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $327,000 project grant under the Aging Research program (CFDA 93.866) to identify clinically relevant cognitive subtypes in preclinical Alzheimer's disease using digital phenotyping methods. The research integrates multimodal data from traditional neuropsychological testing and digital voice recordings to develop computational models that characterize heterogeneous cognitive...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $336,000 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2027. This research initiative evaluates self-reported subjective cognitive concerns (SCC) as an early screening tool for Alzheimer's disease by examining their relationship with longitudinal Alzheimer's disease biomarkers in a diverse, non-demented older...
- Federal Project Grant Award Summary S-3 Research LLC received a $999,556 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 20, 2025, with completion targeted for September 19, 2026. The award supports development of a multi-modal digital tool designed to improve diversity and inclusion in Alzheimer's Disease and Related Dementias (ADRD) clinical trial participation. The deliverables include a trial matching algorithm specific...
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $3.69M Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 15, 2025, through September 14, 2029. The award funds development of specialized Large Language Models (LLMs) designed to optimize comparative effectiveness research (CER) in Alzheimer's disease and related dementias (ADRD). The project addresses a critical gap in real-world evidence by extracting...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Brain Research Africa Initiative $215,995 under the Aging Research program (CFDA 93.866) for a two-year project period (February 1, 2026 through January 31, 2028) to culturally adapt and validate a tablet-based, multi-domain digital cognitive assessment tool for use in Cameroon. The primary deliverables include a validated brief digital cognitive assessment instrument tailored to diverse populations in Cameroon and the...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $852,273 under the Aging Research program (CFDA 93.866) effective September 1, 2025, through May 31, 2030. This Project Grant supports a comprehensive research initiative investigating the role of RNA modifications in Alzheimer's disease (AD) pathogenesis through an integrated approach combining genetics, multi-omics analysis, and functional validation....
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Alabama at Birmingham $5,057,416 under the Aging Research program (CFDA 93.866) for a project grant beginning September 15, 2025, with an ultimate completion date of September 14, 2029. This research initiative addresses critical gaps in understanding undiagnosed Alzheimer's Disease and Related Dementias (ADRD) across the United States. The project will augment Medicare claims data with...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded University of California, Davis a $690,934 project grant effective March 1, 2026, through November 30, 2030, under the Aging Research program (CFDA 93.866). The grant supports a comprehensive research initiative examining subjective cognitive decline (SCD) as an early risk indicator for Alzheimer's disease and related dementias (AD/ADRD) across diverse racial and ethnic populations. The project addresses a critical...
The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $3.41M Project Grant on March 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced diagnostic tools for early detection of mild cognitive impairment and early-stage dementia in Black older adults. The award funds a four-year research initiative (completion: February 28, 2030) that will create the largest corpus of audio-recorded patient-nurse communications from 500 Black patients in home healthcare settings across New York City. The multidisciplinary research team will refine speech-processing algorithms trained on Black verbal language variants (African American English, Caribbean English, and Nigerian English) to identify language impairment as a biomarker for cognitive decline, addressing significant health disparities resulting from underrepresentation of Black speech patterns in existing diagnostic algorithms. The project delivers three primary products: (1) enhanced speech-processing algorithms validated on audio recordings from 250 patients with cognitive impairment and 250 cognitively normal controls; (2) SpeechCare, a multimodal screening algorithm integrating electronic health record data and clinical risk factors with verbal communication features; and (3) a feasibility assessment for implementing SpeechCare as a clinical decision support tool within home healthcare electronic health record systems. This research directly addresses the gap in culturally and linguistically appropriate diagnostic tools that currently contributes to over 50 percent of cognitive impairment cases remaining undiagnosed, with rates exceeding 63 percent in home healthcare settings.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.4m | 2/23/26 |