This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $661,016 to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" project. The key products and services to be delivered include: Establishing an international "Federate AD" alliance to leverage innovative AI techniques and distributed computation to study Alzheimer's disease (AD) across large,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $416,480 to the University of Washington to map the landscape of the aged human brain and develop neurodegenerative disease models. The award will fund a two-phase research project that aims to: 1) identify molecular drivers of brain aging by applying explainable artificial intelligence (XAI) methods to human brain datasets, and 2) manipulate these aging drivers in human induced pluripotent stem...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $802,034 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to develop a Multimodal, Multiscale and Multistage Systems Biology (M3SB) infrastructure for precision medicine in Alzheimer's disease and longevity. The key products and services to be delivered include: Multi-modal analyses of genetics, multi-omics data, cross-species protein interactome...
This federal Project Grant award of $10,774,322, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports the "Multi-Morbidity 3-City Alzheimer's Disease EHR Study (M3AD Study)." The goal is to leverage electronic health records (EHRs) from a multi-ethnic consortium of three large healthcare systems in New York, Chicago, and Miami to better understand how chronic disease trajectories and multi-morbidity complexity impact the incidence, timing, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $466,125 to New York University (NYU) to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to generate brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan, creating a brain microstructure age framework. This framework will then be used to evaluate the effects of...
This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
The National Institute on Aging (NIA), part of the National Institutes of Health within the Department of Health and Human Services, awarded a $2,567,371 Project Grant to The Trustees of Columbia University in the City of New York under the Aging Research program (CFDA 93.866). The grant will fund research from May 1, 2022 to April 30, 2025 to identify cell type-specific autonomous and non-autonomous interactions in Alzheimer's disease (AD) using induced pluripotent stem cell (iPSC) lines from...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $817,357 to the J. David Gladstone Institutes to develop advanced machine learning approaches for comprehensive behavioral and brain signal analysis in humanized Alzheimer's disease mouse models. The key products and services to be delivered include: Validating a machine learning platform called Variational Animal Motion Embedding (VAME) for high-resolution...
The Research Foundation of the City University of New York (RFCUNY), acting as the fiscal administrator for the City University of New York (CUNY), has received a $458,510 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866). This award will support the development of a transformative deep learning framework to integrate multi-omics data and elucidate the molecular mechanisms underlying exceptional longevity (EL). The key objectives are to: 1)...
This Project Grant award of $3,462,615 from the National Institute on Aging (under CFDA Program 93.866 - Aging Research) supports a multi-year research project by The Trustees of Columbia University in New York. The goal is to construct a "multi-organ chart" (referred to as MAE) using advanced AI/ML techniques and large-scale multi-omics data to model the cross-organ biological and pathological effects underlying Alzheimer's disease and aging. The expected outcomes are to establish a reproducible AI/ML-derived framework for personalized susceptibility assessment and to promote the adoption of multi-organ, multi-scale methodologies within the Alzheimer's disease research community. The award period runs from Aug 1, 2025 to Jul 31, 2029.