Project Grant RF1AG091686
Award Date 9/30/25
Completion Date 8/31/29
Dollars Obligated $2.2M
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
College Station, TX, USA
Similar Awards
- This $466,531 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by Texas A&M AgriLife Research to investigate the role of the BIN1 protein in oligodendrocytes and its impact on axon integrity. The research aims to provide new insights into how the BIN1 genetic risk factor may relate to the onset and progression of late-onset Alzheimer's disease. The project will utilize oligodendrocyte-specific BIN1 knockout mice and a...
- This three-year, $4.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The University of South Florida will investigate the role of the BIN1 gene in Alzheimer's disease pathogenesis and neuroinflammatory signaling by microglia. Researchers will generate mouse models lacking BIN1 specifically in microglia to study effects on amyloid plaque burden, tau pathology...
- This three-year, $4,349,236 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The University of South Florida will investigate the role of the BIN1 gene in modulating Alzheimer's disease tau neuropathology in vivo. Researchers will generate cell-type specific inducible BIN1 knockout mice to characterize tau pathogenesis using longitudinal MRI and neuropathology. They will test...
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
- The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,724,674 under the Aging Research program (CFDA 93.866) to Texas Tech University Health Sciences Center in Lubbock, Texas. The three-year project grant beginning September 15, 2022 will support research into the impacts of microrna-455-3p (miR-455-3p) in Alzheimer's disease. Specifically, the grantee will investigate the neuroprotective effects of overexpressing and...
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This federal Project Grant award of $2,316,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop magnetogenetic techniques for manipulating the activity of specific brain cell types implicated in the onset and progression of Alzheimer's disease (AD). The research will focus on using a magnetogenetic tool called FERIC (Ferritin Iron Redistribution to Ion Channels) in combination with enhancer AAV vectors to non-invasively control the activity of AD-vulnerable...
- This $310,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The project has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA-sequencing datasets, and 2)...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...