Project Grant RF1AG091203
- This federal Project Grant award in the amount of $124,875.00 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to Cedars-Sinai Medical Center. The grant supports research by Dr. Larissa Langhi Prata, an Assistant Professor at the Kogod Center on Aging at Mayo Clinic, to investigate the role of senescent cells in the susceptibility of elderly and chronically ill patients to infectious diseases. The research aims to provide insights into the biology of aging and its...
- The National Institute on Aging (NIA) awarded a $1,466,297 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Cedars-Sinai Medical Center, in collaboration with the University of California Los Angeles (UCLA) and the University of Southern California (USC), to establish the Los Angeles Claude D. Pepper Older Americans Independence Center (LA OAIC). This 5-year grant, effective September 1, 2025, aims to extend human healthspan by accelerating and expanding...
- The National Institute on Aging awarded a $462,000 Project Grant to the Albert Einstein College of Medicine in Bronx, NY on August 15, 2025 under the Aging Research federal grant program (CFDA 93.866). The grant supports a two-year research project to map the intrathymic trajectory of β-adrenergic innervation and investigate its role in age-dependent thymic involution. The research aims to create a comprehensive spatial map of β-adrenergic nerve distribution within the thymic stromal network and...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This federal Project Grant award of $145,566 from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting research at the Icahn School of Medicine at Mount Sinai to investigate how the brain accumulates and utilizes "cognitive maps" - internal neural representations that enable flexible behavior and memory recall. The research aims to provide insights into the neuronal coding deficits underlying cognitive decline, with the goal of informing therapeutic...
- The National Institute on Aging (NIA) awarded a $1,459,072 project grant to the J. David Gladstone Institutes under the Aging Research Federal Grant Program (CFDA 93.866) to monitor and manipulate inhibitory interneuron cell populations in mouse models of Alzheimer's disease. The 2-year project aims to use dual cell-type-specific enhancer-associated adeno-associated viruses (enhancer-AAVs) to independently monitor and control parvalbumin (PVALB) and somatostatin (SST) inhibitory interneurons...
- This federal Project Grant award of $2,586,818.00 was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to the Fred Hutchinson Cancer Center in Seattle, Washington. The grant aims to elucidate the mechanisms of communication between adipocytes (fat cells) and the brain, and their impact on glial cell function, neuroprotection, and brain aging. The research will focus on investigating how adipocyte-derived lipoproteins and mitochondrial signals influence...
- This Project Grant award, valued at $2,129,396.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award aims to develop and validate engineered adeno-associated viruses (AAVs) that can selectively knock down the follicle-stimulating hormone receptor (FSHR) in neurons within brain regions vulnerable to Alzheimer's disease. This research seeks to understand the role of FSH signaling in cognitive decline and Alzheimer's...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- The Cedars-Sinai Medical Center was awarded a $419,321 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct a short-term, proof-of-concept study on neurocognitive function profiles in patients with primary and secondary adrenal cortisol insufficiency (ACI), a rare metabolic disorder. The study aims to define neurocognitive function in these ACI subtypes compared to healthy controls using standardized cognitive assessments and patient-reported outcomes....
This $2,591,620 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to Cedars-Sinai Medical Center in California. The grant is designed to determine the role of hypothalamic neurons in the progression of physiological decline with age, with a focus on understanding the cellular mechanisms responsible for increased frailty in older adults. Key objectives include elucidating the role of arginine-vasopressin (AVP) neurons in thermoregulation and fluid balance, exploring the impact of brain inflammation on physiological homeostasis through AVP neuron dysregulation, and investigating the therapeutic potential of gene therapies targeting AVP neurons to address age-related behavioral and physiological frailty. The grant period runs from September 2025 through August 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 9/11/25 |