Project Grant RF1AG090648
- This $605,486 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to define the mechanisms that coordinate late endosome and lysosome functions in neurons. The research aims to address the significant lack of understanding about how the network of proteins that control lysosome function is integrated to meet the unique demands of neurons. This is a critical barrier to understanding the relevance of abnormal lysosome...
- This $1,081,439 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) supports research to uncover the biochemical mechanisms behind cellular aging. The project, titled "TRACING THE COORDINATED CONTROL OF NAD+ HOMEOSTASIS", aims to create a comprehensive database and metabolic map of NAD+ biology throughout the lifespan. This research will investigate how NAD+ metabolism is maintained, regulated, and disrupted as cells age, with...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,208,503.00 to Cornell University to conduct research on the role of autophagy in cellular aging. The project, titled "System-wide and Mechanistic Deconvolution of Autophagy in Cellular Aging", aims to systematically investigate how different forms of autophagy influence cellular aging processes, with a focus on understanding how modulating selective autophagy pathways such...
- This $451,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research by The University of Texas Southwestern Medical Center to investigate the role of the p38 MAPK signaling pathway in regulating lysosome function and tissue integrity during development and aging. The key goals of this 2-year project are to: 1) define the p38 MAPK interactome required for lysosome regeneration, 2) reveal tissue and stage-specific functions of p38 MAPK...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how aging produces ultrastructural alterations to neuronal autophagy, which is critical for maintaining neuronal homeostasis and function. The $429,000 award to the University of Texas Health Science Center at Houston will be used to accomplish two specific aims over the 2-year project period starting January 1, 2025: Compare the ultrastructural features of axonal autophagic...
- This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), supports research to define the molecular mechanisms underlying nucleophagy, the process of nuclear envelope turnover. The $656,709 award to Yale University, spanning 5 years from December 2024 to November 2029, will leverage the yeast model system to map the ultrastructural timeline and molecular machineries involved in this understudied form of autophagy. The...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $227,250 to Saint Louis University to conduct research on the role of the protease Cathepsin L in modulating the nuclear proteome, particularly in the context of premature aging disorders and Alzheimer's disease. The key goals are to: 1) elucidate the mechanism by which Cathepsin L modifies the toxic progerin protein that causes Hutchinson-Gilford Progeria...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $461,313 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Yale University. The funding supports a 2-year research project to investigate the role of the protein CSPalpha in regulating presynaptic autophagy and neurodegeneration. Key objectives include characterizing synaptic vesicles and autophagosomes in wild-type and CSPalpha knockout mouse models, as well...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $921,822 to Yale University to conduct research on the role of the TBK1 gene and its effects on lysosome function in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research aims to elucidate the molecular mechanisms by which TBK1 coordinates lysosome function with cellular demand, including examining the contributions of TBK1...
This federal Project Grant award of $1,565,823.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant supports research to understand the biological mechanisms underlying the autophagy-lysosome system and its role in cellular quality control and aging processes. The principal investigator at Louisiana State University (LSU) aims to investigate how the dynamic transformation of lysosomes into expanded tubular networks can enhance autophagic capacity and promote longevity. By experimentally stimulating the induction of tubular lysosomes, the researchers seek to identify strategies for improving animal health and suppressing age-related disease. The award has a performance period from September 15, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 9/5/25 |