Project Grant R21AG091590

Award Date 9/30/24
Completion Date 8/31/26
Dollars Obligated $461K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New Haven, CT 06519, USA
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The National Institute on Aging (NIA), under the Federal Aging Research program (CFDA 93.866), awarded a $245,148 project grant to Eyenexo LLC to develop an automated rodent behavior testing system for non-invasively assessing early-stage Alzheimer's disease (AD). The project aims to develop a behavior biomarker that can differentiate AD from normal aging by studying defensive behaviors triggered by looming stimuli, which are linked to early AD pathology in the midbrain region. The 2-year...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $461,146 to Yale University to conduct research on the dysregulation of cortical astrocytes in models of Alzheimer's disease. The research aims to: Assess the early loss of state-dependent spatiotemporal dynamics of astrocytic signaling as an initial consequence of Alzheimer's pathology. Investigate the progressive loss of coupling between noradrenergic signaling and astrocyte activity due...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a pilot study to evaluate the feasibility of using non-invasive neuroimaging techniques to monitor the metabolic and vascular functions of the brain and heart in a mouse model of Alzheimer's disease (AD). The $332,096 award, with a performance period from July 2024 to June 2026, will be made to The General Hospital Corporation (doing business as Massachusetts General Hospital). The research...
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This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Yale University totals $460,548 and runs from September 30, 2024 to August 31, 2026. The project aims to develop neuroimaging methodologies for the early detection of Alzheimer's disease (AD) by examining olfactory and memory function in a transgenic rat model. Key activities include:

  1. Longitudinal imaging and behavioral studies on transgenic AD and wild-type rats from early to advanced disease stages (3-12 months) to characterize AD development and progression. This will involve in vivo multi-modal MRI/MRS and behavioral testing to assess functional connectivity alterations in olfactory networks, mitochondrial energy metabolism, and memory/smell abilities.

  2. Leveraging Yale's recent innovations in a novel functional MRI method to enable simultaneous imaging of the rat cerebral cortex and olfactory bulb. The goal is to identify early biomarkers and disruptions in the connectivity between olfactory and memory circuits as potential indicators of AD.

The project seeks to advance the understanding of olfactory and memory deficits as early signs of AD and develop non-invasive neuroimaging techniques for reliable early detection, which could significantly improve treatment and outcomes for patients.

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