Project Grant R825621013

The National Institute of Justice (NIJ) awarded a $319,172 Project Grant under the NIJ Research, Evaluation, and Development Project Grants program (CFDA 16.560) to Research Triangle Institute (RTI International), an independent non-profit research organization. The grant funding will support evaluating the use of direct mass spectrometry technology, specifically the Luxon ion source, to improve the efficiency and capabilities of toxicology laboratories in screening for drugs related to...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...

This Project Grant award of $532,947 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund the development and validation of a unified, cloud-based data processing workflow and database called LC-BINBASE for high-resolution LC-MS/MS metabolomics and lipidomics data. The goal is to create a standardized and reproducible metabolomics data processing system that can be used across different laboratories and mass...

This Project Grant award from the National Institute of Justice (NIJ), under the CFDA program 16.560 "National Institute of Justice Research, Evaluation, and Development Project Grants", provides $119,881 to Florida International University to advance high-resolution mass spectrometry (HRMS) techniques for the detection and identification of new psychoactive substances (NPS). The study aims to systematically evaluate and compare three HRMS platforms - liquid chromatography-quadrupole...

The Commonwealth of Virginia Department of Forensic Science (DFS) received a $371,593 Project Grant from the National Institute of Justice under the Forensics Training and Technical Assistance Program (CFDA 16.044). The funding will support the development and validation of two analytical methods for the identification and quantitation of ethanol and other volatile compounds in biological matrices using headspace gas chromatography. One method will use hydrogen as the carrier gas, and the...

The National Institute of Justice awarded a $392,196 Project Grant under the Forensics Training and Technical Assistance Program (CFDA 16.044) to RTI International. The goal of this 24-month project is to develop a software platform for automating and improving the reliability of colorimetric drug testing, which is a commonly used but limited technique in forensic science. Phase 1 will involve generating test images and defining optimal analysis parameters, while Phase 2 will incorporate machine...

This $190,662 Project Grant award from the National Institute of Justice (NIJ), under the National Institute of Justice Research, Evaluation, and Development Project Grants program (CFDA 16.560), aims to develop methods for the determination of fentanyl analogs in drug mixtures using portable Raman spectroscopy. The primary activities include: 1) Preparing a library of fentanyl spectra and mixtures using optimized surface-enhanced Raman spectroscopy (SERS) methodology; 2) Determining the...

This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...

This two-year, $250,000 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) funds the development of a new high-throughput chemical analysis system for applications such as pharmaceutical drug discovery. The University of California, Berkeley will advance a benchtop nuclear magnetic resonance (NMR) spectroscopy device capable of performing measurements on multiple samples simultaneously at throughput rates 50-100 times greater than current technologies. The...

This $250,000 Project Grant award, provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), will enable Montana State University Billings (MSUB) to acquire an Agilent 1290 Infinity Series II Ultra-High-Performance Liquid Chromatography (UHPLC) system integrated with an Agilent 6530 Quadrupole Time-of-Flight (QTOF) mass spectrometer. This cutting-edge analytical instrumentation will support advanced biomedical research and education at MSUB,...