This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing bispecific antibody-antisense oligonucleotide (BAB-ASO) conjugates to selectively modulate gene expression in neurons. The $618,925 award to the Regents of the University of Michigan aims to accomplish two key objectives: Evaluate the efficacy of a...
The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a $862,420 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Quiver Bioscience Inc., a for-profit biotechnology company. The objective of this 3-year project is to establish an integrated platform that combines machine learning-based antisense oligonucleotide (ASO) design tools and in vitro neuronal functional assays using Quiver's optical...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $400,000 Project Grant to Navega Therapeutics, Inc., a San Diego-based biotechnology company, under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The funding will support Navega's research and development efforts to advance novel epigenetic gene therapies targeting the voltage-gated sodium channel NAV1.7 for the treatment of chronic pain. This innovative approach aims to transiently repress NAV1.7...
This $143,244 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will support research to characterize the impact of SCN8A epileptic encephalopathy mutations on parvalbumin (PV) interneuron function. The research aims to determine whether aberrant PV interneuron excitability contributes to seizures in SCN8A epileptic...
This $415,519 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the role of the SCN1B gene in susceptibility to neuropathic pain. The central hypothesis is that SCN1B, which encodes a key regulator of neuronal excitability, plays a critical part in the development of tactile allodynia in mouse models of neuropathic pain. The research will utilize a combination of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $372,625 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Wisconsin-Madison. The 2-year grant aims to conduct a comprehensive single-cell RNA sequencing study to map gene expression changes in the hippocampus of rat models as they transition from low to high seizure risk states. This pioneering research seeks to identify key...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $971,700.00 to The Regents of the University of California, San Francisco (UCSF) to conduct computational behavioral phenotyping and drug screening for 12 different zebrafish models representing a range of genetic epilepsy conditions. The funding will support the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $145,642.00 to The Trustees of Columbia University in the City of New York to investigate the non-canonical roles of voltage-gated sodium channels (VGSCs) in neurodevelopmental epilepsy. The research aims to examine the influence of the SCN3A gene on cellular migration...
This $279,548 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to characterize unique sodium currents in human dorsal root ganglia (DRG) neurons. The principal investigator at the University of Texas at Dallas (UTD) will use bioinformatics, patch-clamp electrophysiology, and computational modeling to investigate the...
This $666,380 Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to develop a novel cell therapy for treating intractable epilepsy. The funded project aims to scale up production of synchronized early postmitotic human cortical interneurons (CINs) derived from pluripotent stem cells under cGMP...