The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a $862,420 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Quiver Bioscience Inc., a for-profit biotechnology company. The objective of this 3-year project is to establish an integrated platform that combines machine learning-based antisense oligonucleotide (ASO) design tools and in vitro neuronal functional assays using Quiver's optical electrophysiology platform. This aims to improve the predictability of assessing potential central nervous system (CNS) toxicity of ASOs, which are emerging as a transformative approach for treating severe neurological disorders. Key activities include data mining, developing predictive models for ASO-induced acute and delayed CNS toxicity, and creating human iPSC-derived neuronal models to qualify candidate ASOs prior to in vivo evaluation. This work is anticipated to accelerate the development of safer and more effective CNS therapeutics.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $862.4k | 5/20/25 |