Project Grant R61NS138810
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $231,325 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. This 5-year grant will support research to study the neurophysiologic signatures of essential tremor and the implications for deep brain stimulation (DBS) treatment. The...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $679,899 to The University of Texas Southwestern Medical Center to explore the use of Positron Emission Tomography (PET) imaging to measure brain synaptic vesicle glycoprotein 2A (SV2A) as a potential biomarker for essential tremor, a common neurological condition affecting over 7...
- This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
- The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, awarded a $1,499,869 Project Grant to Respirerx Pharmaceuticals Inc. on September 23, 2025. The grant supports the development of a novel GABA receptor potentiator, KRM-II-81, for the treatment of epilepsy. The key objectives of the project include developing the chemistry, manufacturing, and control (CMC)...
- This $1,276,662 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports CND Life Sciences, Inc. to: 1) advance the development of a diagnostic test to identify patients with Essential Tremor (ET) who have deposits of phosphorylated alpha-synuclein, a pathological hallmark of Parkinson's Disease (PD); and 2) determine whether the test...
- This Project Grant award of $743,776 from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) supports research to determine whether and when ablating mutant cells that cause epilepsy can reverse the disease in mouse models of mTOR pathway disorders. The research aims to advance the development of AAV-mediated gene therapy approaches to treat intractable epilepsy caused by mTOR pathway mutations. This work builds upon almost two decades of the recipient...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $690,763 to Brigham & Women's Hospital Inc. to research optimizing neuromodulation therapies for epilepsy. The project aims to identify factors that determine patient response to responsive neurostimulation (RNS), focusing on connectivity, stimulation timing, and background...
- This federal Project Grant award of $140,690 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate the relationship between gamma oscillations in the motor network and dyskinesia (excessive movement) in Parkinson's disease patients. The goals are to use chronically implanted neurostimulators and wearable sensors...
- This federal Project Grant award of $465,500.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research focused on developing a close-loop deep brain optoacoustic stimulation system with sub-millimeter precision. The award was provided to the Trustees of Boston University, a private non-profit research university, to conduct this...
- This federal Project Grant award of $657,958 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research into the cellular and network mechanisms of epilepsy and neuromodulation. The research team from Trustees of Boston University will use cutting-edge cellular membrane voltage imaging, optogenetics, and local field potential recordings in cortical...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is funding research at Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System Incorporated) to optimize new drug compounds for the treatment of essential tremor. The $864,552 award, with a project period from August 1, 2025 to July 31, 2027, aims to develop novel GABAA partial agonists and dual GABAA/beta-2 adrenergic receptor antagonists that can effectively treat essential tremor without the typical side effects of excessive GABAA potentiation, such as sedation. The research focuses on addressing the underlying causes of essential tremor, which is one of the most common neurological disorders affecting an estimated 7 million Americans.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $864.6k | 7/31/25 |