The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,510,066 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to The University of Kentucky Research Foundation to conduct a planning study for the development of sigma 2 ligands as novel analgesics for chronic neuropathic pain. The funding will support an interdisciplinary research team to: (1) develop an in-silico library of potential sigma 2 ligand analogs, (2) synthesize and evaluate 5-10 compounds for in vitro efficacy and drug-like properties, and (3) lay the groundwork for a future U19 proposal to advance the top 1-3 lead compounds towards clinical development. Sub-awards will be provided to researchers at the University of Puerto Rico Medical Sciences Campus, University of Texas at Dallas, New Jersey Institute of Technology, and Arizona State University to contribute specialized chemistry, biology, and structural analysis expertise to the project.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.5m | 9/11/23 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
320000586124094S | University Of Puerto Rico Medical Sciences Campus | Project Grant R61NS127271 | $135.5k | 11/20/23 | |
320000586124096S | Arizona State University | Project Grant R61NS127271 | $133.2k | 10/26/23 | |
320000586124093S | University Of Texas At Dallas | Project Grant R61NS127271 | $497.4k | 10/26/23 | |
320000586124095S | New Jersey Institute Of Technology | Project Grant R61NS127271 | $148.8k | 10/26/23 |