Alternative stimulation mode and location for auditory hallucination neuromodulation treatment
Active Project Grant Awarded Last action
- Award ID
- R61MH128390
- Recipient
-
University Of Texas Health Science Center At Houston UEI ZUFBNVZ587D4 Part of University Of Texas System
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,117,842
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date 72% complete
- Originally
- Place of performance
- Houston, TX 77030, USA
Award details come from USAspending.gov.
Description
- Abstract
- Current efforts to use rtms to treat auditory hallucinations refractory to available antipsychotic medications show promising efficacy but replicability of the effect in well-controlled clinical trials remain unsatisfactory. The proposed study is to use a novel approach to design rtms treatment for auditory hallucination that is based on a strong neural circuitry mechanism on auditory hallucination formation. The project will recruit patients with schizophrenia spectrum disorders and randomize patients into active rtms versus sham rtms groups followed by four fmri based target engagement outcome assessments at baseline and after 10, and 20 visits of daily rtms plus a 2 week maintenance phase. The proposal will use new stimulation site and stimulation mode combinations that are different from previous rtms trials on auditory hallucination, but are conceptualized to be more closely linked to neural circuitry mechanisms of auditory halluciantion formation. The proposal will include two phases as two separate projects. The first proposed project is a R61 for two years. If the go/nogo milestones are not met, the study will end. If all go/nogo milestones are met, IT will proceed to a R33 project for three more years. The trial will test the proposed mechanism of action at brain circuitry level and determine whether the new stimulation site and mode strategy will indeed significantly engage the proposed circuitry of action through modulating its functional connectivity in the direction for improving auditory hallucination.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $551,921 | |
| Original award | $565,921 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| University Of Maryland, Baltimore | $63,724 |
Quick answers
Who received award R61MH128390?
R61MH128390 was awarded to University Of Texas Health Science Center At Houston by National Institute of Mental Health (National Institutes of Health) on September 3, 2024.
How much is award R61MH128390 worth?
$1,117,842 has been obligated on R61MH128390.
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