Project Grant R61CA302550
- The University of California, Los Angeles (UCLA) was awarded a $647,632 Project Grant by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) on March 11, 2025. The grant supports research to develop novel "TNF-ALPHA-ARMED" T-cell receptor (TCR) vectors to enhance the efficacy of adoptive cell therapy for solid tumors. Specifically, the research aims to evaluate the impact of transgenic TNF-alpha co-delivery with tumor antigen-specific TCRs or chimeric antigen...
- The University of California, Los Angeles (UCLA) was awarded a $468,872 Project Grant from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) on May 1, 2025. The grant supports fundamental scientific research and advanced training focused on exploiting the unique properties of perfluorinated compounds to enhance therapeutics, diagnostics, and develop new chemical tools. Key areas of focus include: Designing cyclophane host molecules...
- The University of California, Los Angeles (UCLA) has been awarded a $626,081 Project Grant under the Military Medical Research and Development (CFDA 12.420) federal grant program, administered by the Defense Health Agency. The grant, titled "Combinatorial Phenotype-Targeted Therapy to Overcome Mechanisms Driving Prostate Cancer Treatment Resistance," will support advanced biomedical research to transform healthcare for military service members and the broader public. The research...
- This $235,476.00 federal Project Grant award from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) supports the University of California, Los Angeles (UCLA) in developing new cell-mediated immunotherapeutic strategies for neuroendocrine prostate cancer. The 2-year project, which began on November 1, 2025, aims to transform healthcare for military service members, veterans, and the broader public through innovative and impactful biomedical research....
- The University of California, Los Angeles (UCLA) was awarded a Project Grant of $1,036,293.00 on February 1, 2025 from the National Cancer Institute under the Cancer Research Manpower (CFDA 93.398) federal grant program. The purpose of this 5-year grant is to establish the Neuro-Oncology Translational Research Training Program (NOTR-TP) at UCLA, which will support 1 predoctoral and 3 postdoctoral trainees (including 1 basic scientist and 2 clinician-scientists) in conducting multidisciplinary...
- The University of California, Irvine (UCI) was awarded a $2,186,372 Project Grant under the National Cancer Institute's (NCI) Cancer Biology Research program (CFDA 93.396). The 5-year grant, which began on April 1, 2025, will support a research program focused on understanding the fundamental biological mechanisms of cancer initiation and progression. The program includes three interdisciplinary research projects that will leverage mouse models to investigate the role of stochastic,...
- The University of California, Los Angeles (UCLA) was awarded a $662,086 Project Grant from the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420). The grant will fund research from May 1, 2022 to April 30, 2025 to investigate NUDT5 as a novel target for ovarian cancer. The Military Medical Research and Development program supports basic, applied, and advanced biomedical research with the goal of transforming health care for...
- The National Cancer Institute awarded a 5-year, $667,379 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to the University of California, Irvine (UCI) on February 1, 2025. The grant supports research to decode the role of polyadenylation, a critical mRNA processing step, in health and disease. Key activities include computational modeling to predict the impact of genetic variants on mRNA stability and processing, as well as high-throughput experiments to quantify how...
- The Department of Defense's Military Medical Research and Development program (CFDA 12.420) has awarded a $557,438 project grant to the University of California, Los Angeles (UCLA) to investigate UCHL1 as a novel minimally invasive molecular indicator and therapeutic target for small cell lung cancer. This 2-year research project runs from September 15, 2023 to September 14, 2025 and will be conducted through UCLA's Office of Research Administration division. As a prime grantee, UCLA has also...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $404,972 to the University of California, Los Angeles (UCLA) to conduct research on overcoming radiopharmaceutical therapy resistance in prostate cancer. The key focus is to investigate how the enzyme ENPP1 impacts the effectiveness of PSMA-targeting radiopharmaceutical therapy (RPT) by regulating immune signaling pathways in the tumor microenvironment. The research aims to define...
The University of California, Los Angeles (UCLA) received a $649,181 Project Grant from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) on August 8, 2025. The grant supports UCLA's research to develop enhanced sample preparation reagents and custom proteomics platforms to pinpoint covalent labeling sites that alter protein thermal stability, which can help prioritize high-value therapeutic targets for further mode of action studies. This work builds on UCLA's prior proof-of-concept developments in high-throughput and low-cost screening platforms, as well as multi-dimensional chemoproteomic platforms that report cysteine-dependent changes in protein thermal stability. The grant aims to address unmet needs in cysteine chemoproteomics by improving sample throughput and enhancing the discovery of actionable cysteine residues for cancer drug development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $649.2k | 8/7/25 |