This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) will support research aimed at overcoming resistance to radiopharmaceutical therapy (RPT) in prostate cancer. The $404,972 award, effective August 1, 2025 through July 31, 2027, will enable researchers at the University of California, Los Angeles (UCLA) to investigate how the tumor microenvironment, specifically the enzyme ENPP1, can limit the immune-activating effects of PSMA-targeted RPT. The project will test the hypothesis that ENPP1 inhibition can enhance the anti-tumor immune responses triggered by RPT in prostate cancer models. The research will apply genetic, pharmacological, and imaging approaches to define new mechanisms of RPT resistance and provide the rationale for combination treatment strategies to improve the clinical efficacy of RPT.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $405.0k | 7/23/25 |