Project Grant P01CA288662

Award Date 4/1/25
Completion Date 3/31/30
Dollars Obligated $2.2M
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
California, USA
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This $590,625 Project Grant, awarded by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), supports research to develop a novel therapeutic strategy targeting mutant p53, a key driver of tumor progression and therapy resistance in more than half of human cancers. The principal investigator at the University of California, Davis (UC Davis) will: Determine how mutant p53 expression is regulated by the CDK4/6-RBM38-eIF4G axis and the role of mutant...
The National Cancer Institute (NCI) awarded a $676,584 Project Grant under the Cancer Biology Research program (CFDA 93.396) to The University of Texas MD Anderson Cancer Center. The 5-year grant, which began on April 1, 2025, will support research to investigate the co-evolution of cancer cell genomic alterations and their interactions with the tumor microenvironment during metastatic spread of triple-negative breast cancer (TNBC) to multiple organ sites. The research project aims to...
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  1. Investigating the origins of primary therapeutic resistance and ways to improve existing therapies for chronic myeloid leukemia using an improved mouse model.

  2. Clarifying the cellular states, mutations, spatial arrangements, and microenvironmental factors that contribute to the development of melanoma using mouse models.

  3. Identifying the signals and cell-cell interactions that create and maintain a distinct pre-malignant state, as well as the events that allow rare progression to malignancy, in BRCA1-driven triple-negative breast cancer mouse models.

All three projects will leverage mathematical modeling, genomics, and computational biology, and will be supported by a shared resource core for single-cell data analysis and access to new technologies. The program aims to advance the understanding of non-genetic and non-cell-autonomous processes driving cancer development, which could lead to improved prevention and therapeutic strategies.

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