Project Grant R61AI197037
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $3.02 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) beginning August 8, 2025, with a completion date of July 31, 2029. This award supports the design and development of single-shot sequential immunization regimens for HIV using atomic layer deposition (ALD) technology. The research builds upon preclinical successes...
- Federal Grant Award Summary The Scripps Research Institute received a $910,905 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2025, through February 12, 2026. This award supports the development and characterization of HIV vaccine candidates using a novel lipid nanodisc platform technology. The project delivers scalable, in vitro characterization and...
- Federal Grant Award Summary The Scripps Research Institute received a $511,531 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 13, 2026, with a completion date of January 31, 2031. The project focuses on advancing HIV vaccine development through the characterization and optimization of engineered transmembrane envelope (ENV) protein candidates using a lipid nanodisc...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a Project Grant totaling $1,285,304 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and evaluate an enhanced HIV vaccine regimen capable of producing durable broadly neutralizing antibody (BNAB) responses. The research, which commenced August 1, 2025, and extends through July 31, 2030, leverages a novel six-shot germline-targeting...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $506,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 9, 2025, with a completion date of June 30, 2027. The award supports the development of high-throughput technologies for generating and screening small interfering RNA (siRNA)-peptide conjugates designed to improve delivery efficiency for viral infection...
- Grant Award Summary The Scripps Research Institute received a $1.38 million Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 21, 2025, through July 31, 2030. The award supports systematic research aimed at engineering durable immunity through optimization of HIV vaccine parameters to drive long-lived plasma cell development. The research will examine three...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $899,935 to the Scripps Research Institute under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 10, 2025, to identify novel B cell epitopes against human coronaviruses. The research will utilize an integrated platform combining comprehensive characterization, high-resolution structural determination, state-of-the-art multi-bait B cell isolation strategies, and...
- Federal Project Grant Award Summary Emory University received a $954,603 project grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded April 9, 2026, with completion targeted for March 31, 2028. The award funds the development of a biodegradable and biocompatible nanoparticle injectable sterile formulation that encapsulates ALG-001075, a novel capsid assembly modulator with pan-genotypic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Salk Institute for Biological Studies a Project Grant totaling $515,625 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period February 10, 2026 through January 31, 2028. The research deliverables focus on elucidating the molecular pathways and mechanisms underlying drug resistance development in HIV-1 integrase inhibitor (INSTI) therapy. The project will...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $184,000 in project grant funding to the Scripps Research Institute under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2028. The research deliverable focuses on elucidating the proximal regulation of innate immune signaling pathways relevant to ischemia/reperfusion injury (IRI), specifically examining how the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $899,741 Project Grant effective April 1, 2026, through March 31, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports research and development of a long-acting injectable (LAI) therapy for hepatitis B virus (HBV) treatment in individuals co-infected with human immunodeficiency virus (HIV), addressing a significant public health need affecting approximately 10% of the 1.2 million people living with HIV in the United States. The research deliverables are structured in two phases. During the R61 phase, Scripps will optimize the lead entecavir prodrug candidate (MCMQ657) through pre-formulation and formulation development to achieve sustained release for up to three months, while conducting preclinical pharmacokinetic and pharmacodynamic studies, toxicology assessments, and safety pharmacology evaluations in animal models to support candidate identification. The R33 phase focuses on investigational new drug (IND)-directed development activities, including good manufacturing practice (GMP) process development, good laboratory practice (GLP) toxicity studies, regulatory strategy development, and preparation for future clinical trials, culminating in a pre-IND meeting with the Food and Drug Administration.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $899.7k | 3/30/26 |