Project Grant R61AG094645
- The National Institute on Aging awarded The Johns Hopkins University a $622,086 Project Grant on May 15, 2025 under the Aging Research federal grant program (CFDA 93.866) to elucidate the mechanisms driving microglial activation by amyloid-beta oligomers and assess the involvement of the NOD2/RIPK2 signaling pathway in neuroinflammation and neurodegeneration in Alzheimer's disease. The project aims to characterize the role of NOD2/RIPK2 signaling in Alzheimer's disease and explore its...
- The National Institute on Aging (NIA) awarded a $1,459,072 project grant to the J. David Gladstone Institutes under the Aging Research Federal Grant Program (CFDA 93.866) to monitor and manipulate inhibitory interneuron cell populations in mouse models of Alzheimer's disease. The 2-year project aims to use dual cell-type-specific enhancer-associated adeno-associated viruses (enhancer-AAVs) to independently monitor and control parvalbumin (PVALB) and somatostatin (SST) inhibitory interneurons...
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- This $2,220,145 federal Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), aims to optimize and develop novel cell-type-selective adeno-associated virus (AAV) vector technologies to study disease-relevant cell types and neural circuits in mouse models of aging and Alzheimer's disease. The key products and services to be delivered include: Developing enhanced AAV vectors that can genetically target and manipulate specific brain cell...
- The National Institute on Aging awarded a Project Grant of $455,274 to The Johns Hopkins University on May 15, 2025 under the Aging Research Federal Grant Program (CFDA 93.866). The objective of this project is to develop and apply statistical methods to improve scientific inferences in Alzheimer's disease (AD) research when using cross-sectional or longitudinal study designs. The proposed approaches aim to handle age-specific prevalent cases in case-control studies, develop regression methods...
- The National Institute on Aging (NIA) awarded a $842,175 Project Grant under the Aging Research program (CFDA 93.866) to the J. David Gladstone Institutes in San Francisco, CA. The grant, awarded on December 15, 2024, will fund research to explore the role of the NOX2 enzyme in mediating Alzheimer's disease (AD) pathologies, including network hyperactivity, glucose hypometabolism, and accumulation of amyloid-beta and tau proteins. The research aims to assess the therapeutic efficacy of a novel...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- This federal Project Grant award of $480,710 from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Johns Hopkins University is focused on investigating a novel vascular pathway that regulates neuronal survival. The project aims to understand how a specific enzyme, glycerophosphodiester phosphodiesterase 2 (GDE2), functions in vascular endothelial cells to release a protein required for neuronal survival, and how disruptions in this pathway may contribute to neurodegenerative...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $461,313 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Yale University. The funding supports a 2-year research project to investigate the role of the protein CSPalpha in regulating presynaptic autophagy and neurodegeneration. Key objectives include characterizing synaptic vesicles and autophagosomes in wild-type and CSPalpha knockout mouse models, as well...
The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $1,083,046 Project Grant under the Aging Research program (CFDA 93.866) to The Johns Hopkins University. The grant, running from August 1, 2025 to July 31, 2027, will support the development of novel adeno-associated viruses (AAVs) to selectively manipulate oligodendrocyte precursor cells (OPCs) in the central nervous system. The project aims to test the hypothesis that reactive transformation of OPCs surrounding amyloid plaques in Alzheimer's disease models can reduce plaque burden. This research effort seeks to advance scientific understanding of glial cell responses to aging and disease, and the consequences of these changes on neural homeostasis and circuit function.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/5/25 | ||
| Not listed | $1.1m | 7/29/25 |