The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has awarded a $187,031 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of California, Los Angeles (UCLA) to investigate the effects of chronic alcohol exposure on astrocyte-derived exosomes and their role in alcohol-induced neuronal dysfunction.
The two-year research project aims to: 1) develop an in vivo model for tracking astrocyte-derived exosomes and profiling their RNA contents, and 2)...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $211,247 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Southern California (USC) for a Phase II clinical trial evaluating the effectiveness of the dual GLP-1/GIP receptor agonist tirzepatide in reducing alcohol consumption and improving weight outcomes among adults with co-occurring alcohol use disorder and overweight/obesity. This 2-year study will expedite research on a promising...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will fund research to investigate the neuroepigenetic mechanisms underlying the transgenerational effects of alcohol exposure.
The $148,568 award will enable the primary grantee, the University of California, Los Angeles (UCLA), to conduct studies using the C. elegans model system to identify the specific neuronal...
This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), aims to develop functional connectivity-guided transcranial magnetic stimulation (FCG-TMS) as a novel treatment for alcohol use disorder (AUD).
The $174,067 grant will fund a two-phase study to: 1) characterize the spatial patterns of TMS cortical targets in relation to alcohol cue-reactivity, and 2) evaluate the efficacy of a single...
This $223,531 federal Project Grant was awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to the University of North Carolina at Chapel Hill. The funding will support research on the role of perineuronal nets (PNNs) in adolescent alcohol-induced deficits. Specifically, the project will enzymatically degrade PNNs in the orbitofrontal cortex of rats exposed to adolescent intermittent ethanol (AIE) and measure the...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $243,783 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of California, Los Angeles (UCLA) to conduct a clinical neuroscience study on stress coping mechanisms in alcohol use disorder (AUD). The study aims to objectively assess chronic stress and examine dynamic functional connectivity within the brain's stress coping system using fMRI in 32 individuals with AUD and 32 matched controls....
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $231,364 to the University of Washington to examine the feasibility of implementing the Families Moving Forward (FMF) Bridges early intervention program for infants and toddlers affected by prenatal alcohol exposure (PAE) or fetal alcohol spectrum disorders (FASD). The study will be conducted in two phases - a small initial trial with...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $223,531 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of North Carolina at Chapel Hill (UNC-CH). The 2-year grant, effective September 2024 through August 2026, will fund the development and testing of novel 3D human "reciprocal brain circuits" to investigate the role of microglia (immune cells) in the neuronal pathology associated with alcohol use disorder (AUD) and...
This $499,442 Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research examining the role of brain-derived neurotrophic factor (BDNF) signaling in the ventral hippocampus (VHP) and its contribution to the acute anxiolytic and social effects of alcohol, as well as the potential promotion of alcohol preference over social interaction when BDNF signaling is disrupted....
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $412,125 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Research Foundation For The State University Of New York to study the impact of prenatal alcohol and methadone exposure on the regulation of dopamine signaling and synaptic plasticity in the basolateral amygdala. The two-year project aims to determine how the combined exposure to prenatal alcohol and methadone alters social and non-social...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $265,510 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of California, Los Angeles (UCLA) to conduct a clinical trial investigating the use of trigeminal nerve stimulation (TNS) to treat prenatal alcohol exposure (PAE) in children. The R61 pilot phase will initially assess the feasibility and safety of using TNS in children with PAE, while the subsequent R33 phase will involve a formal double-blind, sham-controlled randomized clinical trial to rigorously evaluate the efficacy of TNS for PAE. Alongside the clinical trial, the grant will also support measurements of brain imaging endpoints to elucidate the neural mechanisms underlying TNS's therapeutic effects for this condition. The award period runs from September 2024 through August 2026.