Project Grant R56NS147433
- The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $459,143 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate a mouse model of temporal lobe epilepsy suitable for drug screening. The funded work addresses the lack of animal models amenable to pharmaceutical testing for temporal lobe epilepsy, a debilitating disorder affecting millions worldwide. The...
- The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $444,125 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mechanisms and treatments for post-stroke seizures and epilepsy using a murine model. The work spans two aims. Aim 1 tests the effects of post-stroke argathroban (a direct thrombin inhibitor) and levetiracetam (an anti-epilepsy drug) on ameliorating early...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Emory University $420,142 on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to explore the contribution of extracellular vesicles to epileptogenesis in temporal lobe epilepsy and Dravet syndrome. The research examines how extracellular vesicles—small membranous particles...
- The National Institute of Neurological Disorders and Stroke awarded $242,250 to the University of Virginia on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds research into myeloid cell regulation of cerebrovascular tone and function, specifically investigating how microglia and perivascular macrophages maintain baseline vascular structure and blood flow in the brain and facilitate vascular responses...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Baylor College of Medicine $560,954 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R01NS146728). The award funds research into synaptic inhibition during spontaneous seizures in vivo, using all-optical tools to measure principal neuron depolarization and inhibitory postsynaptic...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded the University of California, Davis $548,368 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing designation). The project, "Slow-Wave Sleep Enhancement to Treat Epilepsy and Its Comorbidities" (R01NS147124), addresses the hypothesis that...
- The National Institute of Neurological Disorders and Stroke awarded Cincinnati Children's Hospital Medical Center $1.614 million on September 11, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic research on epileptogenesis mechanisms in mtoropathies and develop AAV-mediated gene therapy approaches for intractable epilepsy caused by mTOR pathway mutations. The research leverages newly developed mouse models of...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $150,512 on August 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into controlling epilepsy symptoms through precisely timed inhibition and circuit editing, focused on temporal lobe epilepsy and cognitive impairments associated with seizure disorders. The research employs closed-loop...
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University Medical Center $688,785 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate arousal network dysfunction in temporal lobe epilepsy. The research examines how recurrent consciousness-impairing focal seizures in temporal lobe epilepsy patients affect subcortical arousal networks and contribute to long-term...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Virginia $236,896 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to explore the link between enteric glial cells and multiple sclerosis etiology. The research investigates the hypothesis that enteric glial cells in the gastrointestinal tract may...
The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $565,250 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate microglial mechanisms in status epilepticus recovery. The research tests two hypotheses on how microglia facilitate seizure termination and recovery from prolonged seizures. Aim 1 investigates the role of microglial P2RY12 receptor inhibition of ferroptotic mechanisms in status epilepticus termination using genetic, transcriptomic, and molecular approaches. Aim 2 examines the molecular contribution of complement signaling in microglial process pouch formation around injured dendrites and documents the structural and functional consequences of these pouches. Prior work by the investigator demonstrated that microglia and microglial P2RY12 receptors facilitate seizure termination and that microglia form pouches around injured dendrites following seizures to facilitate their restoration independent of P2RY12. Performance occurs in Charlottesville, Virginia, with a period of performance from September 1, 2026, through August 31, 2027. The award is classified as a Project Grant, an assistance type supporting extramural research in neurological disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $565.3k | 8/21/26 |