Project Grant R56NS140453
- The National Institute of Neurological Disorders and Stroke awarded Augusta University Research Institute, Inc. $462,933 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation into spreading depolarization (SD), a wave of sustained neuronal and glial depolarization associated with migraine aura and recognized as a mechanism of injury in stroke and traumatic brain injury. The research...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $555,000 to Augusta University Research Institute, Inc. on May 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds development of a novel optogenetic assay to study intracellular transport defects in neurodevelopmental diseases. The research addresses how motor...
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University $394,915 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate and augment cholinergic signaling for enhanced neuroprosthetic performance. The research targets mechanisms that accelerate learning and control of brain-computer interfaces (BCIs) for paralyzed patients. Current intracortical neuroprosthetic implants have...
- The National Institute of Neurological Disorders and Stroke awarded Colorado State University $496,279 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cholinergic synaptic homeostasis and the molecular mechanisms regulating compensatory changes in synaptic strength in response to altered neural activity. The recipient will use Drosophila as a genetically tractable model system to study central...
- The National Institute of Neurological Disorders and Stroke awarded the University of Rochester $1,606,088 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate spatiotemporal control of cerebral blood flow by purinergic signaling networks. The project examines neurovascular coupling—the process by which cerebral blood flow rapidly directs to active brain regions to meet metabolic demands—with specific focus...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Wake Forest University $533,623 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating mechanisms that protect neurons from glutamate excitotoxicity during metabolic stress. The research uses avian neurons, which naturally resist...
- The National Institute of Neurological Disorders and Stroke awarded $439,875 to the University of California, San Diego on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cholinergic regulation of epidermal neurons. The research examines how acetylcholine constrains growth in peripheral sensory neurons through the muscarinic acetylcholine type 1 receptor (M1R), with particular focus on the role of...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Albany Medical College $1.951689 million on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of inflammation-resolution pathways to address vascular contributions to cognitive impairment and dementia (VCID) in the context of atherosclerosis....
- The National Institute of Neurological Disorders and Stroke awarded $402,347 to the University of Georgia Research Foundation, Inc. on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing 93.853) to develop an extracellular vesicle-based platform for delivering healthy mitochondria to nerve cells affected by neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer's disease, and...
- The National Institute on Aging awarded Virginia Commonwealth University $552,883 on January 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the selective vulnerability of cholinergic neurons in Alzheimer's disease. The award is a Project Grant with performance extending through November 30, 2030, at the Richmond, Virginia campus. The funded research investigates how soluble oligomeric amyloid-beta 42 (oAB42) drives selective degeneration of basal forebrain...
The National Institute of Neurological Disorders and Stroke awarded $539,000 to Augusta University Research Institute, Inc. on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of sub-pallidal basal forebrain activation to increase acetylcholine levels in the cerebral cortex, with applications to electrical stimulation therapy currently in clinical trials. The research comprises three aims: direct visualization of acetylcholine level changes in the cerebral cortex using fluorescent acetylcholine receptor imaging technology; pharmacological studies applying acetylcholinesterase inhibitors and feedback autoreceptor modulators to alter cholinergic processing; and viral vector manipulation of molecules in the cholinergic circuit to optimize acetylcholine recycling from release through hydrolysis, choline transport, re-conjugation, and re-packaging in vesicles. The work leverages expertise of three principal investigators through the multi-PI mechanism. Performance occurs in Augusta, Georgia. The period of performance runs from September 1, 2026 through August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $539.0k | 8/27/26 |