The National Institute of Mental Health (NIMH) awarded a $252,125 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The Trustees of Columbia University in the City of New York to conduct research on the neural mechanisms underlying context-dependent decision-making. The research aims to use functional magnetic resonance imaging (fMRI) in mice to identify brain regions involved in maintaining contextual information to guide decisions, and then employ optogenetics...
The National Institute of Mental Health (NIMH) awarded a $823,252 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Trustees of Princeton University on September 18, 2024. The grant will support a 5-year research project titled "CROSS-BRAIN, MULTI-REGION INTERACTIONS IN DECISION FORMATION AND DECISION COMMITMENT" that aims to enhance the understanding of the neural mechanisms underlying decision-making processes. The grant includes a $55,255 sub-award to The Johns...
This Project Grant award of $857,903 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is funding research to leverage computationally derived measures of individual differences in learning and decision-making to predict psychiatric diagnosis, symptoms, and changes in symptom severity over time. The primary goal is to develop reliable, robust computational measures of cognitive processes that are meaningfully relevant to psychiatric...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is providing $107,948.00 to The Johns Hopkins University to study the computational mechanisms underlying single neuron activity within brain-wide circuits. The research aims to characterize the relationships between synaptic input patterns and action potential generation in cortical neurons, investigate how inputs change when the brain drives specific neuron...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $189,540 to the University of Pittsburgh to investigate the role of cortico-striatal circuitry in model-based decision-making. The key objectives of this 5-year research project are to: 1) determine how model-based control is represented in distinct cell types in the prelimbic cortex and dorsomedial striatum, 2) assess whether direct and indirect...
The National Institute of Mental Health (NIMH) awarded a $1,401,862 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the University of California, Berkeley. The 5-year grant, which commenced on September 21, 2024, will support research to investigate the role of the orbitofrontal cortex (OFC) in inhibiting habitual responses in the striatum to enable goal-directed decision-making. The researchers will use a novel behavioral task and advanced neural recording...
This federal Project Grant award of $389,735.00 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program. The project aims to identify the neural correlates of mental simulation in multi-step planning, which is essential for decision-making and is often impaired in psychiatric and neurological disorders. The research team at New York University will use a combination of fMRI, MEG neuroimaging, and eye-tracking to study the...
This federal Project Grant award of $1,920,113, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports a research project titled "Narrowing the Mechanistic Gap for Anterior Prefrontal Cortex Function". The project aims to conduct a deep dive on the anatomy and function of the anterior lateral prefrontal cortex (ALPFC) region of the brain, which has been implicated in various mental health disorders such as...
This $1,338,397 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to understand spatial representations in the orbitofrontal cortex (OFC) of rats and their role in value-based decision making. The primary awardee, the University of California, Los Angeles (UCLA), will develop two novel behavioral tasks for rats that require spatial credit assignment - the "patch-leaving task" and...
This National Institute of Mental Health (NIMH) Project Grant award, under the Mental Health Research Grants (CFDA 93.242) program, provides $389,400 to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on the circuit-level computational deficits underlying compulsivity in humans. The project aims to characterize and potentially correct these deficits by pairing repeat measures of cognitive processes like inhibitory control and reversal learning with direct neural...