This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $774,632 to Northwestern University to conduct research on the neural basis of dopamine-driven deficits in cognition and perception. The research aims to determine how excess dopamine impacts the activity of D1 and D2 dopamine receptor-expressing spiny projection neurons in the dorsal striatum, and how this relates to working memory and...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research at Northwestern University to investigate the microcircuit mechanisms underlying distributed cortical contributions to working memory in mice. The $553,788 award, effective January 1, 2025 through December 31, 2029, will leverage advanced imaging and optogenetic techniques to compare how genetically-identified cell types in the primary...
This $731,035 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the neurological mechanisms underlying auditory hallucinations in a mouse model of 22q11.2 deletion syndrome, a genetic disorder associated with a high risk of schizophrenia. The key objectives are to: 1) Test whether mimicking the 22q11.2 deletion syndrome abnormalities, such as reduced thalamic output and...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,505,818 to Rosalind Franklin University of Medicine & Science to investigate the role of the neurexin protein in social adaptation and amygdala plasticity. The research aims to determine how disruption of the neurexin 1 gene impacts synaptic plasticity within the prefrontal cortex-amygdala circuit, which is critical for flexible social...
This federal Project Grant award, titled "DISTINCT NMDA RECEPTOR SIGNALING DOMAINS REGULATE HIPPOCAMPAL NETWORK DYNAMICS", is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $231,547 grant will support research at George Mason University over a 2-year period from August 1, 2024 to July 31, 2026. The research project aims to investigate the role of NMDA receptor signaling in regulating hippocampal network...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,694,945 to the Lieber Institute for Brain Development (LIBD) to conduct research on understanding the cellular and circuit mechanisms underlying schizophrenia. The key products and services to be delivered under this award include: 1) Replicating and expanding on prior findings from 2D cell culture models of patient-derived induced...
This $711,361 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research at Loyola University of Chicago's Health Sciences Campus to investigate sex differences in the impact of prenatal stress on cognitive function. The research aims to determine if disruptions in RNA editing of the GluA2 subunit of AMPA receptors in the hippocampus and amygdala mediate the long-term detrimental effects of...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $811,404 to The Trustees of Columbia University in the City of New York to conduct research on the neural circuit mechanisms underlying anticipatory anhedonia in schizophrenia. The key objectives of this 5-year research project are to: 1) Establish the relationship between anticipatory value computation and anhedonia traits through...
The National Institute of Mental Health (NIMH) awarded a $775,706 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Pittsburgh to conduct a prospective study on the neural, molecular, and functional impacts of anticholinergic medication reduction in 80 individuals with mid- to late-life schizophrenia spectrum disorders. The 6-year study, which began on Aug 9, 2024, aims to understand the effects of anticholinergic burden reduction on cognition, quality of life,...
This $735,932 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to elucidate the mechanisms underlying positive symptoms of schizophrenia, such as auditory hallucinations. The award, with a performance period from April 2025 to January 2030, will be conducted by St. Jude Children's Research Hospital Inc. in Memphis, Tennessee. The key objectives are to characterize the disruption of...