This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $1,122,296 to the University of Illinois to investigate the role of cellular senescence in the development of mustard gas keratopathy (MGK). The research aims to: 1) study the relationship between senescence, inflammation, and corneal disease progression following acute exposure to nitrogen mustard; and 2) develop a new model to examine the role of...
This $589,071 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) is funding research to investigate the immune mechanisms driving chronic ocular damage after acute exposure to nitrogen mustard, a potent chemical warfare agent. The key objectives are to: (1) determine how the acute innate corneal response to mustard exposure activates a persistent pathogenic T-helper 17 (Th17) immune response, and...
This Project Grant award by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $583,250 to The Schepens Eye Research Institute, Inc. to identify the mechanisms underlying ocular toxicity caused by nitrogen mustard exposure and evaluate specialized lipid mediators as potential medical countermeasures. The key objectives are to: 1) Determine how nitrogen mustard alters the function of conjunctival goblet cells and if...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program provides $498,248 to the University of Connecticut Health Center (UCHC) to investigate the molecular mechanisms underlying corneal and retinal injury caused by exposure to chemical threat agents like nitrogen mustard. The key objectives are to: 1) Examine the role of the p53-PAD axis in driving corneal hypercitrullination, a pathological response, after nitrogen...
This Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) will provide $482,242 to The Medical College of Wisconsin, Inc. to conduct research on the mechanisms of mustard gas toxicity in the retina using a minipig model. The project aims to characterize the in vivo clinical, structural, and functional changes in the retina of a minipig model exposed to mustard gas, and identify molecular targets involved in retinal degenerative...
This Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $536,233 to Northwestern University to develop a synthetic melanin-based treatment to accelerate wound healing and reduce scarring resulting from exposure to mustard gas. The project aims to evaluate a group of synthetic melanin particles (SMPs) for their ability to mitigate initial skin injury and promote faster wound repair...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding of $1,426,622 to The Washington University to conduct research on the neural mechanisms underlying corneal injuries caused by ammonia exposure. The key objectives are to: Correlate the delayed corneal wound regeneration with the extent of corneal nerve degradation in mouse models, and quantify the associated ocular pain behaviors. Delineate the activating mechanism of corneal sensory...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $317,239 to the University of Texas Medical Branch at Galveston (UTMB) to investigate conserved inflammatory mechanisms of vesicant-induced skin injury. The research aims to map the distribution of transcriptional pathways and biomediators associated with localized damage from exposure to sulfur mustard and lewisite vesicants using...
The U.S. Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $1,477,500 Project Grant to The Schepens Eye Research Institute, Inc., a non-profit organization affiliated with Harvard Medical School and Massachusetts Eye and Ear. The 3-year grant, awarded on September 1, 2023, will fund research on "Topical Calcitonin Gene-Related Peptide for Corneal Injury Prevention and Regeneration." The Schepens Eye Research Institute, which has...
This $251,250 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports research to characterize inflammatory cell infiltration in the meibomian glands and investigate the role of autoimmune CD4+ T cells in causing meibomian gland dysfunction (MGD), a leading cause of dry eye disease affecting millions. The award funds a collaborative research project between Baylor College of Medicine, which serves as the prime recipient, and the University of Houston College of...