Project Grant R56DK143951
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $133,333 Project Grant to Yale University to study the mechanisms underlying the myeloid bias in aged hematopoietic stem and progenitor cells (HSPCs). The research aims to correct this myeloid bias by preventing the turnover of the linker histone H1.0, which could have implications for addressing diverse...
- This federal Project Grant award of $560,100 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate how environmental exposures, such as industrial pollution and catastrophic events, lead to hematopoietic stem cell dysfunction and the progression of clonal hematopoiesis. The project, awarded to the Albert Einstein College of Medicine in Bronx, NY, will...
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $388,749 to The Washington University in Missouri to conduct research focused on understanding the impact of clonal hematopoiesis on the aging human bone marrow. The goal is to investigate how these somatic mutations that can drive leukemia exist and interact within the bone marrow niche in cancer-free adults, which may yield insights into how these pre-malignant states...
- This federal Project Grant award of $196,460 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to determine how inhibiting the migration of immature neutrophils during obesity affects hematopoietic stem and progenitor cells, metabolism, and systemic inflammation. The award, made on Jun 23, 2025, is to The Trustees of Columbia University in the...
- This federal Project Grant award of $154,860 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research on the mechanisms of clonal competition in age-related clonal hematopoiesis. The grant, awarded to The Children's Hospital Corporation (Boston Children's Hospital), aims to investigate factors that drive the expansion of "super-competitor" clones bearing DNMT3A mutations, which are associated with increased risk of hematologic diseases...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Vanderbilt University Medical Center (VUMC) a $150,000 Project Grant under CFDA 93.847, the Diabetes, Digestive, and Kidney Diseases Extramural Research program. The grant, which runs from Sep 1, 2023 to Aug 31, 2024, will fund a study to identify factors that contribute to clonal expansion and disease progression in clonal hematopoiesis of indeterminate potential (CHIP). The research aims to dissect the...
- This $147,486.00 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of high-fat diet in hematopoiesis (blood cell formation) and clonal hematopoiesis, a condition associated with increased risk of myeloid diseases like myelodysplastic syndrome and acute myeloid leukemia. The award was made to the Regents of the University of Michigan, Ann Arbor for a project period running from Jul 9,...
- This Project Grant award of $742,391 from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) supports research conducted by Tufts University School of Medicine to develop an in vivo model system that can recapitulate the development and evolution of clonal hematopoiesis (CH) during aging, tumorigenesis, and cancer treatment. CH is a premalignant condition associated with increased risk of hematologic malignancies, particularly in cancer patients undergoing...
- This Project Grant award of $125,532.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the disruption of the clonal architecture of human hematopoietic stem cells driven by high-effect somatic and germline genetic variants, and identify the resulting phenotypic changes that lead to impaired stem cell function and increased disease risk with aging. The research will utilize a mitochondrial lineage tracing...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
This $133,315 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by the University of Rochester to investigate the impact of bone turnover and local inflammatory profiles on the expansion of clonal hematopoiesis (CH) in live animal models. The project aims to establish a robust methodology for tracking CH clones and skeletal dynamics through longitudinal intravital imaging. Specifically, the research will determine how physiological bone remodeling alters immune cell phenotypes within the bone marrow cavity, and characterize the niche occupancy and lineage contribution of mutant CH clones in an ultralow-dose irradiated model over one year. The award period runs from September 15, 2025 to August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.3k | 9/11/25 |