This federal Project Grant award of $429,000 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the unique mechanisms by which osteoblasts in the jawbone respond to bone morphogenetic protein (BMP) signaling and mechanical loading, compared to long bones. The research team at the University of Michigan will use single-cell RNA sequencing and proximity labeling...
The federal Project Grant award R01DE034804, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the potential mechanisms underlying peri-implantitis, a common condition affecting dental implants. The $582,000 award, with a project period from May 1, 2025 to January 31, 2030, will enable the University of Rochester to study the role of inflammation, oxidative stress,...
The National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, awarded a $847,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Utah. The 2-year grant, awarded on August 1, 2023, will fund research to develop and evaluate the efficacy of a novel antimicrobial bone scaffold made from zinc-doped fluorapatite for use in craniofacial surgical applications. The research aims to...
This $304,019 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) aims to develop a novel antibody-based therapy to prevent alveolar bone loss in severe periodontitis. The funding will support the identification and evaluation of a panel of human anti-human OC-STAMP monoclonal antibodies, with the goal of selecting a lead candidate to be tested in a ligature-induced...
This $320,053 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports a comprehensive research study on the mechanisms regulating skeletal connectivity in craniofacial development and disease. The research led by Dr. Amy Merrill at the University of Southern California aims to decode the molecular identities of craniofacial connective tissue cells, reveal their role in joint...
This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to elucidate how the protein Kalirin regulates the function and viability of osteocytes, the most abundant bone cells, across different skeletal sites with a focus on periodontal bone. The $109,548 award, with a project period from September 1, 2025 to May 31, 2027, will fund studies using osteocyte-targeted...
This federal Project Grant award of $109,548.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to elucidate the regulatory role of the RUNX2 transcription factor in postnatal dentin synthesis and alveolar bone formation. The study aims to uncover RUNX2-regulated pathways that could serve as therapeutic targets for dentin and alveolar bone repair and regeneration. Additionally, the...
This Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, will fund research into the genetic basis of human skeletal facial morphology through July 2025. Provided under the Oral Diseases and Disorders Research program (CFDA 93.121), the $936,510 in funding will support two key aims. First, the awardee will enhance current mesh landmarking procedures for craniofacial bone by developing a dense quasi-landmark...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $222,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Children's Hospital of Philadelphia (CHOP) Research Institute. The grant, effective from August 1, 2024 to July 31, 2026, will support research to investigate the pathogenic mechanisms underlying temporomandibular joint (TMJ) osteophyte formation. Specifically, the project aims to test the hypothesis that a steep local...
This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The research aims to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC) cells contributes to pain processing and the tumor microenvironment. The project will evaluate...