Project Grant R56AR085837
- The federal Project Grant award of $3,204,624.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, supports research to define the molecular and cellular mechanisms of non-canonical inflammasome responses to lipopolysaccharide (LPS) in mice and humans. The research aims to provide essential insight for developing improved therapeutics to reduce human sepsis, as well as immune adjuvants to enhance host...
- This federal Project Grant award of $1,024,897.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund research at the University of Pennsylvania to dissect the role of innate immune cell responses, particularly inflammatory monocytes and neutrophils, in controlling intestinal and systemic Yersinia infection. The research aims to define how a monocyte-driven TNF-IL-1 signaling circuit mediates control of Yersinia...
- This federal Project Grant award of $446,875.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher novel cell death mechanisms and metabolic reprogramming in response to microenvironmental stress. The primary awardee, The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, will leverage their expertise in...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
- The federal Project Grant award of $300,000 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to Temple University in Philadelphia, PA. The funding supports research focused on understanding the role of the kallikrein-kinin system and its ability to suppress the type I interferon response, which is a hallmark of systemic lupus erythematosus (SLE). The research aims to explore new pathways for interferon suppression and their...
- The federal Project Grant award, totaling $448,250.00, was granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to support the development of sulfonium lipid nanoparticles (SLNPs) as a novel platform for mRNA delivery. The primary objective is to expand the chemical diversity of sulfonium lipids, investigate their unique physicochemical and biological properties, and explore the therapeutic potential of...
- This federal Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $173,480.00 to the University of Illinois to elucidate the mechanisms through which circulating CD14+ monocytes drive the inflammatory-fibrotic axis of advanced pulmonary sarcoidosis-related fibrosis (APSF). The award aims to use single-cell RNA sequencing and surface protein indexing to identify key regulators and signaling pathways within...
- This federal Project Grant award, worth $786,456.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of the University of Pennsylvania for the project "IMPACT OF PIGA LOSS ON HEMATOPOIETIC STEM CELL FUNCTION" from August 1, 2025 to May 31, 2030. The goal of this research is to identify the mechanisms underlying the expansion of phosphatidylinositol glycan type A (PIGA) gene-mutated...
- This $240,552 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a research project titled "Unraveling the Cell Networks in Bone Marrow Through Transcriptomic and Epigenetic Profiling" at the University of Pennsylvania. The project aims to generate a comprehensive single-cell transcriptomic and regulomic map of human bone marrow cells and experimentally establish the mesenchymal cell hierarchy in human bone....
- The federal Project Grant award of $108,512 was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The award will fund research to determine how inflammation is regulated in Runx1-Familial Platelet Disorder (Runx1-FPD), a genetic disorder that increases the risk of hematologic malignancies. The research aims to...
This federal Project Grant award for $300,000.00 was provided by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The award was granted to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to support the research project "INNATE LYMPHOID CELLS AND TERTIARY LYMPHOID STRUCTURES IN SARCOIDOSIS". The project aims to advance scientific understanding in the biomedical and health-related domain of sarcoidosis by investigating the role of innate lymphoid cells and tertiary lymphoid structures. This 1-year award, with a period of performance from Sep 1, 2025 to Aug 31, 2026, reflects the NIH's commitment to funding high-impact, transformative research across diverse scientific disciplines to address complex health challenges.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 8/25/25 |