This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $605,253 to The Trustees of the University of Pennsylvania to investigate the mechanical crosstalk between the intervertebral disc and adjacent facet joints during spinal degeneration and repair. The research aims to characterize the progression of facet osteoarthritis following disc...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 Arthritis, Musculoskeletal and Skin Diseases Research will support research to investigate the role of DNA methylation in intervertebral disc degeneration and chronic low back pain. The $658,385 award will fund a 5-year project to: 1) Identify the DNA methylation and gene expression landscape in human intervertebral disc degeneration and discogenic low back pain, 2)...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $752,620 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Washington University, a prominent private research institution, to develop injectable, cell adhesive, and growth factor-presenting alginate hydrogels that enhance the therapeutic potential of mesenchymal stem cells (MSCs) for intervertebral disc (IVD) repair. The project aims to modify alginate gels to...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $568,462 to the University of Virginia to conduct research on targeting monocyte infiltration to treat acute and chronic back pain. The goal is to determine the roles of early and late-infiltrating monocytes at disc herniation sites and identify disease-modifying therapies. The research...
This Project Grant award of $459,820.00, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the role of mitochondrial respiration and bioenergetic metabolism in regulating the differentiation of growth plate chondrocytes. The award will enable researchers at the University of Pennsylvania to investigate how the loss of the mitochondrial...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,037,340 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the Broad Institute, Inc. The grant aims to transform the Musculoskeletal Knowledge Portal (MSKKP) into an established biomedical knowledgebase that integrates curated 'omics datasets, processes them through analytical pipelines, and presents the results through web-based visualizations. The...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the role of glutamine metabolism in regulating osteoclast differentiation and bone resorption. The $588,302 award, with a project period from February 1, 2025 to January 31, 2030, will be conducted by The University of Texas Southwestern Medical Center. The key...
This Project Grant award of $473,377 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research to modulate the stem cell niche and improve skeletal muscle regeneration. The key objectives are to: Interrogate how muscle cells arise and develop functional characteristics from human pluripotent stem cells (hPSCs) through analysis of myogenic commitment factors and inhibition of...
This $483,070 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" supports research into the dynamics of bone extracellular matrix (ECM) assembly and resorption. The study aims to investigate how osteogenic cellular dynamics, differentiation, and cell fate are integrated with collagen assembly and mineralization, as well as how osteoclast bone resorption...
This federal Project Grant award of $456,808.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of advanced mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in musculoskeletal tissues. The primary awardee, the Buck Institute for Research on Aging, is collaborating with researchers at the University of...