From microcin sequence to function: linking sequence variation to antimicrobial activity
Active Project Grant Awarded Last action
- Award ID
- R56AI179799
- Recipient
-
University Of Texas At Austin UEI V6AFQPN18437 Part of University Of Texas System
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,379,734
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 80% complete
- Originally
- Place of performance
- Austin, TX 78759, USA
Award details come from USAspending.gov.
Description
- Abstract
- New approaches to antibiotic development are needed to combat multidrug-resistant bacteria, and especially gram-negative pathogens. The gram-negative outer membrane prevents most molecules from entering the cell and is one of the greatest hurdles to new antibiotic development. A remarkable strategy to overcome this permeability barrier is shown by the new clinical antibiotic cefiderocol, which binds outer membrane siderophore receptors and uses active transport systems to pull itself into the periplasm. Using energy-coupled import allows otherwise exclude molecules, like the antibacterial component of cefiderocol, to enter bacteria. Unfortunately, few molecules capable of this translocation have been identified, and we have been largely limited to using siderophore conjugates to develop these innovative trojan horse antibiotics. Our work on the understudied class of bacteriocins called microcins provides a rare opportunity to study a broader class of antibacterials with this membrane translocation ability. Microcins are small antibacterial proteins (
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $72,618 | |
| Amendment | $653,558 | |
| Original award | $653,558 |
Quick answers
Who received award R56AI179799?
R56AI179799 was awarded to University Of Texas At Austin by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on June 24, 2024.
How much is award R56AI179799 worth?
$1,379,734 has been obligated on R56AI179799.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award