Control of drosophila intestinal homeostasis by RHOGAP15B

Ended Project Grant Awarded Last action

Award ID
R56AG085250
Recipient
Awarding agency
Obligated
$381,022

Award facts

Assistance listing
93.866 Aging Research
Completion date
Originally
Place of performance
Georgia, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The overall goal of this proposal is to understand how organisms as diverse as humans and the fruit flies use the same molecules to decide when and where cells will divide, especially when they are needed to repair damaged tissues. The specific focus of this application is a protein that is highly conserved from insects to humans, and appears to act specifically in the adult GUT to support stem cell renewal of this tissue over the organism's lifespan. Despite its apparent importance to GUT homeostasis, the protein has not been the subject of sustained study. Our preliminary data indicate that acts as a signaling hub that receives inputs from phospholipids and in turn delivers regulatory outputs onto two highly conserved pathways broadly involved in human health and disease. We are very excited to leverage the strength of our data to understand how this protein coordinates these various roles within intestinal stems cells in drosophila. Our own cells have a version of this protein, so we believe that our work will shed light on mechanisms that support our stem cells too.

Transactions

Action Obligated Date
Amendment $0
Original award $381,022

Quick answers

Who received award R56AG085250?

R56AG085250 was awarded to Emory University by National Institute on Aging (National Institutes of Health) on September 15, 2024.

How much is award R56AG085250 worth?

$381,022 has been obligated on R56AG085250.

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