Project Grant R50CA305824
- This Cooperative Agreement award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $809,106 to The Washington University from September 1, 2025 through August 31, 2030 to accelerate the expert crowdsourcing of cancer variant interpretation through the CIVIC (Clinical Interpretations of Variants in Cancer) web resource. CIVIC is a community-driven platform that centralizes and standardizes expert-curated interpretations of cancer-related genetic...
- This federal Project Grant award of $237,007 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) funds the development of two complementary software tools to facilitate cancer dependency research. The first tool aims to enable biomedical researchers without advanced computational skills to predict and interpret cancer dependencies through an intuitive, web-based interface powered by large language models. The second tool will create a scalable, modular...
- This federal Project Grant award of $584,510.00, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports the development of advanced spatial transcriptomics and proteomics technologies for studying tumor microenvironments. The award enables the University of Colorado-Denver to implement new imaging techniques and computational approaches to enhance the capabilities of its Human Immune Monitoring Shared Resource (HIMSR). This will allow...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), provides $155,000.00 to support Michael Sauria, PhD, as a Research Software Engineer in the Andersen Lab at Johns Hopkins University. The primary goals are to improve the underlying infrastructure and user experience of the Caenorhabditis Natural Diversity Resource (CaenDR), which leverages natural genetic variation across nematode...
- This $993,446 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical cooperative programs of genes and genomic elements. The goal is to produce computational tools and workflows that can identify and rank functionally disease-critical...
- This federal Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) provides $153,348 to The Trustees of Columbia University in the City of New York to conduct in-depth mechanistic and in vivo functional studies of single-nucleotide variants (SNVs) that modulate T cell activity for cancer immunotherapies. The research aims to define the mechanisms by which certain PIK3CD SNVs enhance T cell activity and evaluate their impact in murine...
- This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $501,618 to the Dana-Farber Cancer Institute, Inc. (DFCI) to develop new computational tools for accurately calling germline and mosaic sequence variations, including variants from long RNA-seq reads, mosaic structural variants, and integrated small and structural variants. The project aims to address critical gaps in existing long-read variant calling tools by creating...
- This three-year Project Grant from the National Science Foundation's Division of Information and Intelligent Systems under the Computer and Information Science and Engineering program ($600,000) will support the development of new computational methods and software for analyzing collections of genomic variants. Specifically, the grantee, Carnegie Mellon University, will create algorithms and open-source software tools to more accurately construct, compare, and assess the complexity of genome...
- This federal Project Grant award of $412,295 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on sequence transformations and computational biology at Carnegie Mellon University. The award period runs from September 1, 2025 to August 31, 2030. The research focuses on advancing the theory and software tools for approximate string matching in biological sequences, which is critical for...
- This Project Grant award of $154,000 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research software engineering work for the SimVascular open-source project at Stanford University. The funding will enable Dr. David Parker, a Research Software Engineer in the Marsden Lab, to make essential contributions over a 3-year period from August 2025 to May 2028. This includes code improvements, development and integration of new features, enhancing...
This federal Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $155,500 over 3 years from September 1, 2025 to August 31, 2028 to support the work of lead software engineer Adam Coffman at Washington University in St. Louis. The funding will enable Mr. Coffman to continue his contributions to the development of the CIVIC platform, an open-access, community-driven web resource for clinical interpretation of cancer variants. Key deliverables include building tools to help reduce the bottleneck of editorial review, such as dependent task assignment, automated variant coordinate curation, and variant pathogenicity scoring. Mr. Coffman will also develop novel visualization and search capabilities to enhance user access to the data available in CIVIC. Additionally, he will ensure CIVIC remains current with emerging data standards for variant representation developed by the Global Alliance for Genomics and Health and other relevant bodies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.5k | 8/29/25 |