Project Grant R35GM160134
- This $300,000 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports the development of probabilistic string similarity sketching software for metagenomics and RNA-seq analysis. The research aims to provide rigorous mathematical proofs for the analysis techniques used in genome alignment and apply these methods to the discovery of new protein variants and measurement of RNA levels in cells. The project will analyze the average-case...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop novel high-throughput machine learning approaches to study cell population-wide differences in subcellular object morphology, conformations, and organization using cryo-electron tomography (cryo-ET) data. The $371,427 award, granted on June 10, 2025, will support Carnegie Mellon University in addressing...
- This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to develop improved computational methods for human gene annotation. The $387,500 award to The Johns Hopkins University will fund efforts to adapt and expand their existing StringTie software system, a genome-guided transcriptome assembler, to process large-scale RNA sequencing data and build a comprehensive,...
- This $241,506 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "SOS: BIO: The Anatomy of Scientific Biomedical Open-Source Software--From Code to Communities" at Carnegie Mellon University. The key objectives of this 24-month project are to: (1) identify and characterize the biomedical open-source software (OSS) infrastructure through...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $323,642 Project Grant to Carnegie Mellon University (CMU) on September 1, 2025. The grant supports a 5-year research project to develop new mathematical and computational models for understanding how the complex spatial structure of biological populations, such as cancer cells, microbial colonies, and human populations, influences their evolutionary dynamics. The project aims to create...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports advanced quantitative analyses of long-read RNA sequencing data at both the bulk and single-cell levels. The $424,264 award, effective June 1, 2025 through May 31, 2030, will enable the University of Michigan to build upon their expertise in long-read sequencing bioinformatics and deliver new insights into...
- This federal Project Grant award of $1,968,575.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing computational approaches and machine learning methods to predict DNA-binding specificities for transcription factor proteins and the functional effects of genetic variants within proteins. The overarching goal is to gain a predictive understanding of proteins, their interactions,...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- This three-year Project Grant from the National Science Foundation's Division of Information and Intelligent Systems under the Computer and Information Science and Engineering program ($600,000) will support the development of new computational methods and software for analyzing collections of genomic variants. Specifically, the grantee, Carnegie Mellon University, will create algorithms and open-source software tools to more accurately construct, compare, and assess the complexity of genome...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $2,252,479.00 to the Trustees of Dartmouth College to develop new computational models inspired by evolutionary biology that can detect cellular proliferation, differentiation, and migration from single-cell sequencing data. The goal is to decode the mechanisms of human diseases by reconstructing the history of these...
This federal Project Grant award of $412,295 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on sequence transformations and computational biology at Carnegie Mellon University. The award period runs from September 1, 2025 to August 31, 2030. The research focuses on advancing the theory and software tools for approximate string matching in biological sequences, which is critical for applications like genome assembly, phylogenetic analysis, and detecting horizontal gene transfer. The university has developed innovative sequence transformation techniques and associated bioinformatics software, including SKANI for fast and accurate pairwise genome comparisons and SKANDIVER for detecting mobile genetic elements. This award will enable the continued development of rigorous mathematical theory and high-performance computational tools to address fundamental challenges in computational biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $412.3k | 9/1/25 |