Project Grant R50CA252146
- The University of California, San Diego (UCSD) was awarded a $1,583,640 Cooperative Agreement by the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to advance the use of spatial metabolomics for cancer research. The project aims to further develop the open-source METASPACE software platform to support the analysis of large, complex datasets generated through spatial metabolomics techniques like imaging mass spectrometry. This technology enables mapping of metabolite abundances...
- The National Cancer Institute (NCI) awarded a $953,922 Cooperative Agreement under the Cancer Biology Research program (CFDA 93.396) to the Scripps Research Institute in California. The funding supports research to understand the fundamental links between RNA modifications, codon usage, translation, and metabolism in cancer cells. The overall goal is to identify correlations between modification states of the translation apparatus and changes in codon occupancy and translation rate, and map...
- This $534,083.00 Project Grant was awarded on June 3, 2025 by the National Cancer Institute, under the Cancer Biology Research Federal Grant Program (CFDA 93.396), to the University of California, San Diego (UCSD). The grant supports research investigating how breast cancer cell-derived extracellular vesicles can lead to overproduction of glucocorticoids, or "stress hormones," and how this affects normal cells to facilitate breast cancer metastasis. The key goals are to: (1) identify...
- This $285,599 Project Grant was awarded on September 22, 2025 by the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to Sinopia Biosciences Inc., a San Diego-based company specializing in computational drug discovery and advanced metabolomics research. The funding will support the development of a unique metabolomics-enabled AI/ML platform to systematically characterize a chemical library of ~3,300 small molecules and identify metabolic signatures that can predict cancer drug...
- The National Institutes of Health (NIH) awarded a Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Leland Stanford Junior University, totaling $1,033,055 with a project period from Sep 8, 2025 to Aug 31, 2030. The grant aims to develop an effective therapy for solid tumors by targeting a newly discovered survival characteristic - nanoscale membrane curvature - that is crucial for cancer cell survival during metastasis. The project seeks to unravel the molecular...
- The National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) awarded a $185,760 Project Grant to the University of Chicago on September 15, 2025 for the research project "Targeting Glycerol Metabolism in Anti-Tumor Immunity". The project aims to investigate the role of glycerol metabolism in tumor-immune interactions, with a focus on understanding how cancer cells can impair the anti-tumor functions of CD8+ T cells, especially in the context of obesity. The research...
- The University of California, Irvine (UCI) was awarded a $2,186,372 Project Grant under the National Cancer Institute's (NCI) Cancer Biology Research program (CFDA 93.396). The 5-year grant, which began on April 1, 2025, will support a research program focused on understanding the fundamental biological mechanisms of cancer initiation and progression. The program includes three interdisciplinary research projects that will leverage mouse models to investigate the role of stochastic,...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $544,478 to The University of Texas Southwestern Medical Center to conduct research on "Decoding the Metabolic Routes of Purine Nucleotides in Cancer". The overarching goal is to expand the mechanistic understanding of purine synthesis pathways in tumors and identify new strategies to target purine supply mechanisms for effective cancer treatment. Key research aims include:...
- The National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) awarded a $649,181 Project Grant to the University of California, Los Angeles (UCLA) to develop enhanced sample preparation reagents and a custom proteomics platform for high-throughput, multidimensional chemoproteomics. The goal is to pinpoint covalent labeling sites that alter protein thermal stability, in order to prioritize high-value targets for further mode of action studies related to cysteine-reactive...
- The National Institutes of Health (NIH) awarded a $1,710,000.00 Project Grant to the Salk Institute for Biological Studies in La Jolla, California under the Trans-NIH Research Support program (CFDA 93.310). The purpose of this 3-year grant, effective September 22, 2023, is to develop novel tools and model systems to track the dynamic interactions between rapid signaling, stress and metabolic responses, transcriptional changes, epigenetic modifications, and genetic alterations that contribute...
The National Institutes of Health National Cancer Institute awarded a $366,439.80 Project Grant to the University of California, San Diego to support research identifying and exploiting metabolic vulnerabilities in cancer. The grant supports the work of Thekla Cordes, an expert in dissecting cancer metabolism through metabolic systems biology approaches, who will develop and apply mass spectrometry-based analytical techniques to quantify metabolite levels and metabolic fluxes in diverse cancer settings using 13C, 15N, and 2H tracing approaches. Cordes will also establish anchorage-independent cell culture models and genetically engineered cell lines to gain insights into metabolic reprogramming in cancer under the Cancer Biology Research program (CFDA 93.396). This five-year award beginning September 21, 2021 provides protected research time for Cordes to directly support the goals of the NIH-funded research project "Non-Essential Amino Acids and Sphingolipid Diversity in Cancer Progression" through quantitative analysis of central carbon, lipid, and redox metabolism as well as biochemical investigation of pathways involving amino acids and sphingolipids.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($69k) | 6/16/22 | ||
| Not listed | ($69k) | 6/16/22 | ||
| Not listed | $0 | 2/9/22 | ||
| Not listed | $0 | 2/9/22 | ||
| Not listed | $0 | 2/9/22 |