Cooperative Agreement U01CA305256
- This Cooperative Agreement award of $922,755.00 from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports research at the University of Massachusetts Medical School (UMASS Medical) aimed at understanding the role of tRNA modification and translational remodeling in cancer progression and metastasis. The project will use advanced RNA mass spectrometry, sequencing, and ribosome profiling techniques to comprehensively catalog tRNA modification dynamics...
- This $941,798 Cooperative Agreement was awarded by the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to the Beckman Research Institute of the City of Hope, a nonprofit medical research organization in California. The funding supports research to investigate the molecular mechanisms of codon-biased translation, a process that cancer cells hijack to promote their survival and therapeutic resistance. Specifically, the project will explore the role of the ALKBH1 enzyme in...
- This $850,611 Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) will support research at the University of Texas Southwestern Medical Center to investigate the role of tRNA modifications in regulating mitochondrial activity and cancer metastasis in renal cell carcinoma. The project aims to examine how overexpression of dihydrouridine synthase enzymes, which introduce dihydrouridine modifications in tRNAs, impacts the translation of...
- This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) provides $1,583,640 to the University of California, San Diego (UC San Diego) from June 23, 2025 to May 31, 2028 to advance spatial metabolomics research for cancer. The project aims to develop and apply the METASPACE open-source software platform to enable data analysis and interpretation of large, complex spatial metabolomics datasets generated through imaging mass spectrometry techniques....
- This $150,104 federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) to Yale University supports research to determine the regulatory role of dose-sensitive 5-methylcytosine (m5C) modifications on mRNA translation initiation and their impact on cancer. The project aims to screen approximately 35,000 human 5' untranslated regions (5'-UTRs) for m5C installation by the methyltransferases NSUN2 and NSUN6, and quantify ribosome recruitment to these...
- This federal Project Grant award, funded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports research focused on understanding the relationship between inflammatory signaling in the leptomeninges and the growth of leptomeningeal metastatic tumors. The $730,398 award to the Sloan-Kettering Institute for Cancer Research, located in New York, will leverage mouse models and single-cell RNA sequencing to investigate how cancer cell signals induce...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- This Cooperative Agreement award for $639,882, funded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports research at the University of North Carolina at Chapel Hill to elucidate the molecular mechanisms of metastasis organ tropism in breast cancer. The key objectives are to: Identify molecular determinants of lung and liver organ-specific metastasis using a comprehensive dataset of human primary tumors and metastases, as well as genetically...
- This Cooperative Agreement award of $556,865.00 was provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the Trustees of Tufts College to conduct research on "Stiffness-Mediated Genetic Selection of Cells". The project aims to investigate how the mechanical properties of a cell's substrate can drive the evolution of cell phenotypes and genotypes over sustained culture periods. The research will quantify how cell behaviors like growth, motility, and...
- This Cooperative Agreement awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $1,281,520.00 in funding to The Leland Stanford Junior University to conduct research on the fundamental biological mechanisms of cancer metastasis, organ tropism, and immune evasion. The project aims to integrate genetic barcoding with single-cell profiling to uncover the key molecular drivers underlying metastatic fitness and diverse cancer cell states in pancreatic ductal...
This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $953,922.00 in funding to the Scripps Research Institute in California to conduct research on the links between RNA modifications, codon use, translation, and metabolism in cancer cells. The overall goal is to identify correlations between modification states of the translation apparatus and changes in codon occupancy and translation rate across cancer cell lines, particularly in relation to methionine starvation and its impact on cancer cell growth. This research aims to improve understanding of how methionine starvation may mediate or limit cancer cell growth, which could inform therapeutic targeting of this pathway. The project will run from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $953.9k | 8/20/25 |