Project Grant R44NS135867
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $619,189 to Massachusetts Institute of Technology on August 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to establish a bioelectronics-integrated mesoscale organ-on-a-chip platform for neuromuscular disease modeling. MIT will develop a limb-on-a-chip platform that...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $428,218 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop subcellularly resolved spatial genomics approaches for studying axon regeneration. The research maps the nerve regenerative landscape by building a three-dimensional spatial single-cell transcriptomics atlas of dorsal root ganglia in mice, training a...
- The National Institute of Neurological Disorders and Stroke awarded the Sloan-Kettering Institute for Cancer Research $484,000 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research characterizing and inhibiting interactions of the alpha-secretase ADAM17 with the neuronal-myelin signaling complex upon spinal cord injury. The study investigates how myelin-associated inhibitors—including...
- The National Institute of Neurological Disorders and Stroke awarded Trace Biosciences Inc. $448,711 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop molecular imaging agents for detecting and monitoring myelin loss in demyelinating diseases including multiple sclerosis and Charcot-Marie-Tooth disease. Trace Biosciences is advancing a platform of myelin-specific small-molecule near-infrared fluorophores...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Johns Hopkins University $1.5 million on September 15, 2026, under the Biological Sciences program (CFDA 47.074) to investigate action potential propagation in unmyelinated axons. The project examines whether sodium and potassium channels concentrate in wider sections of unmyelinated axons and whether membrane shape controls channel insertion and function. Unmyelinated axons lack the myelin insulation of...
- The National Institute of Neurological Disorders and Stroke awarded The Broad Institute, Inc. $404,282 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to engineer transferrin receptor 1 (TFR1) binding adeno-associated virus (AAV) capsids that evade pre-existing neutralizing antibodies while maintaining central nervous system delivery capability. The funded research addresses a critical barrier to AAV gene therapy for...
- The National Institute on Aging awarded Jackson Laboratory $486,750 on June 15, 2026, under the Aging Research program (CFDA 93.866) to engineer a human glial-neuronal microphysiological system for studying myelination and axonal-synaptic pathology in Alzheimer's disease. The project develops a tri-culture platform integrating neurons, astrocytes, and oligodendrocytes on a microfluidic system to enable axonal maturation, myelination, and synaptic connectivity under physiological conditions. This...
- The National Institute of Neurological Disorders and Stroke awarded $427,625 to the University of Washington on May 19, 2026, to identify axon length-dependent gene expression programs and their role in neurodegenerative disease vulnerability under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders. The recipient will systematically identify genes whose expression levels covary with axon length and characterize their functional roles in length-dependent...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $551,557 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nucleic acid sensing pathways in demyelinating disease. The funded research dissects the role of endosomal toll-like receptors (eTLRs) in neuroinflammation and demyelination, specifically examining how aberrant eTLR signaling in...
The National Institute of Neurological Disorders and Stroke awarded Artificial Axon Labs Inc. $1.478 million on August 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a biomimetic drug screening platform for remyelinating therapies targeting multiple sclerosis. Artificial Axon Labs, an MIT spinout based in Beverly, Massachusetts, is developing artificial axons—a three-dimensional printed drug discovery platform designed to model the environment of demyelinating lesions and identify first-in-class compounds that promote myelin repair. Current disease-modifying MS therapies prevent new inflammatory lesions but do not address remyelination of prior damage; existing drug screening assays are either too complex for efficient use or provide unphysiological environments that do not reflect actual axon-myelin interaction. The artificial axons platform uses biomimetic materials with stiffness properties that match nervous tissue, enabling high-throughput screening of remyelinating drug candidates under conditions mimicking the inhibitory environment present in MS lesions. The award obligates $1.478 million with a performance period extending through July 31, 2028. Work is performed in Beverly, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 8/6/26 |