Project Grant R44NS147800
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Oregon Health & Science University $858,000 on September 24, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds in vivo investigations of astrocyte-oligodendrocyte interactions using molecular, genetic, cellular, and proteomic tools to define astrocyte-oligodendrocyte myelin interactions at the...
- The National Institute of Neurological Disorders and Stroke awarded $616,577 to the Research Institute At Nationwide Children's Hospital on August 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to elucidate cellular and molecular disease mechanisms in Charcot-Marie-Tooth type 1B disease and develop gene therapy approaches. The recipient will pursue two aims. In Aim 1, the institute will determine how myelin protein zero...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $618,001 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate deuterium metabolic spectroscopy and imaging (DMS/I) as a technique for non-invasively measuring brain glucose and ketone metabolism in multiple sclerosis. The project uses deuterium-labeled metabolic tracers to investigate how energy...
- The National Institute of Neurological Disorders and Stroke awarded Artificial Axon Labs Inc. $1.478 million on August 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a biomimetic drug screening platform for remyelinating therapies targeting multiple sclerosis. Artificial Axon Labs, an MIT spinout based in Beverly, Massachusetts, is developing artificial axons—a three-dimensional printed drug discovery platform...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,001,831 on August 20, 2026, to validate [18F]3F4AP PET as a biomarker for peripheral nerve injuries under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds a phased R61/R33 study to develop and validate [18F]3F4AP, a novel PET radioligand, for detecting and quantifying...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $551,557 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nucleic acid sensing pathways in demyelinating disease. The funded research dissects the role of endosomal toll-like receptors (eTLRs) in neuroinflammation and demyelination, specifically examining how aberrant eTLR signaling in...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- The National Institute of Neurological Disorders and Stroke awarded the University of Missouri System $574,083 on March 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a vector-based therapeutic for Charcot-Marie-Tooth disease type 2E (CMT2E) using a novel mouse model. The recipient will develop a precision medicine approach to treating CMT2E, which is caused by mutations in the neurofilament light gene (NEFL). The...
- Federal Grant Award Summary Research Triangle Institute (RTI International) received a $547,846 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2027. The award supports research focused on the optimization and characterization of small molecule GPR17 (G protein-coupled receptor 17) antagonists for...
- The National Institute of Neurological Disorders and Stroke awarded New York University $247,300 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop quantitative MRI methods for assessing white matter injury and repair. The project integrates multi-shell, multi-diffusion time MRI with large-scale three-dimensional electron microscopy and quantitative immunofluorescence to establish how diffusion and T2-based...
The National Institute of Neurological Disorders and Stroke awarded Trace Biosciences Inc. $448,711 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop molecular imaging agents for detecting and monitoring myelin loss in demyelinating diseases including multiple sclerosis and Charcot-Marie-Tooth disease. Trace Biosciences is advancing a platform of myelin-specific small-molecule near-infrared fluorophores to enable high-contrast in vivo imaging of nerve tissue. The recipient has synthesized and screened over 400 oxazine-based fluorophore candidates and advanced two lead agents—LGW16-03 and IT14-63—through IND-enabling studies, demonstrating safety, pharmacokinetic robustness, and compatibility with human nerve tissue. Both compounds distinguish healthy from demyelinated tissue in the peripheral and central nervous systems with high sensitivity and directly bind myelin to report on Schwann cell and oligodendrocyte health. Period of performance runs through August 31, 2027. Work is performed in Beaverton, Oregon. The award is structured as a Project Grant, the standard assistance type for this program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $448.7k | 9/3/26 |