This Project Grant award of $414,191 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Drexel University investigating the relationship between structural variations in alpha-synuclein (α-syn) protein fibrils and the development of distinct neurodegenerative synucleinopathies such as Lewy body dementia, Parkinson's disease, and multiple system atrophy....
This $655,329 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to determine the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The research team at Albert Einstein College of Medicine will use CRISPR/Cas9 genome editing in human pluripotent...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $682,493 to the Albert Einstein College of Medicine to elucidate the role of aberrant histone acetylation in the pathogenesis of Parkinson's disease and related synucleinopathies. The research involves utilizing a human pluripotent stem cell-based discovery platform...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) provides $728,408 to investigate novel genetic variants that confer susceptibility to pesticide-induced Parkinson's disease. The award aims to biologically validate candidate gene variants identified in a prior epidemiological study, using iPSC-derived human dopaminergic neuron cultures and a mouse model of paraquat-induced Parkinsonism. The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $645,391 to investigate the effects of re-expressing embryonic motor neuron transcription factors on disease pathology in amyotrophic lateral sclerosis (ALS) models. The research aims to determine if restoring these developmental regulators can enhance the ability of mature motor...
This $1,002,148 federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the role of autophagy, a cellular mechanism for clearing damaged organelles and harmful materials, in neurological diseases like Parkinson's, Alzheimer's, and ALS. The research aims to determine how the regulation of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $450,313 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Johns Hopkins University to develop high-throughput screening (HTS) assays to identify activators of the nemo-like kinase (NLK) protein. The goal is to find small molecule compounds that can lower mutant huntingtin (mHTT) protein levels as a potential therapeutic approach for Huntington's...
This federal Project Grant award of $231,255 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to identify the tissue source and functional properties of plasma-derived alpha-synuclein strains associated with Parkinson's disease (PD). The five-year grant, awarded to the University of Pennsylvania, aims to use extracellular vesicles to uncover the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" supports research focused on developing a nano scavenger-based diagnostic and therapeutic strategy for Parkinson's disease. The $799,127 award to Baylor College of Medicine aims to establish the preclinical potential of a nano scavenger agent that can bind to and facilitate clearance of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $431,750 R21 project grant (CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders) to Rutgers, The State University of New Jersey to study the role of the RIPK3 protein in protecting neurons from excitotoxicity during Zika virus infection. The two-year project will use a combination of pharmacogenetics, imaging, molecular biology, and electrophysiology to investigate how RIPK3...