Project Grant R44MH140727
- The National Institute of Mental Health awarded The Leland Stanford Junior University $192,192 on April 15, 2026, to develop an artificial intelligence foundation model for functional neuroimaging that predicts treatment response, stratifies patients, and identifies biotypes in major depressive disorder under CFDA 93.242 (Mental Health Research Grants). The award funds three specific aims. Aim 1 applies pooled functional MRI data from individuals with major depressive disorder to fine-tune a...
- Federal Project Grant Award Summary The National Institute of Mental Health awarded Empathy Rocks Inc. a Project Grant of $447,132 under the Mental Health Research Grants program (CFDA 93.242) for the period September 1, 2025 through August 31, 2026. The awardee will develop an artificial intelligence tool designed to standardize the administration and scoring of Clinical Outcome Assessments (COAs) in mental health clinical trials. This Phase I Small Business Innovation Research (SBIR) project...
- The National Institute of Mental Health awarded Brigham & Women's Hospital Inc. $863,825 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a double-blind, confirmatory efficacy trial comparing imaging-based targeting versus scalp-targeted accelerated transcranial magnetic stimulation (ATMS) for treatment-resistant major depressive disorder. The trial will enroll 120 participants to test whether imaging-targeted ATMS, using Stanford Accelerated...
- The National Institute of Mental Health awarded Northwestern University $714,760 on July 21, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a neuroimaging ancillary study investigating dopaminergic mechanisms of depression and antidepressant response in persons with HIV. The study will enroll 48 participants from a larger clinical trial comparing pramipexole (a dopamine agonist) against escitalopram (an SSRI) for antidepressant efficacy in major depressive...
- The National Institute of Mental Health awarded Dream Face Technologies LLC $314,362 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and evaluate robot-administered cognitive behavioral therapy for older adults with depression. Dream Face Technologies will conduct a Phase I Small Business Innovation Research study using the Ryan Companionbot, an AI-powered humanoid socially assistive robot, to assess and treat older adults aged 65 and older with...
- The National Institute of Mental Health awarded Oregon Research Behavioral Intervention Strategies, Inc. (doing business as Influents Innovations) $314,362 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to develop a digital evidence-based app for providers and teens addressing depression and subclinical depressive symptoms in youth. The project addresses the gap between the prevalence of depressive symptoms in adolescents and access to treatment. Cognitive...
- The National Institute of Mental Health awarded Miresource, Inc. $1.744 million on September 12, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop a longitudinal mental health monitoring platform that generates personalized care guides and treatment referrals. Miresource will integrate software solutions, curate mental health content, and employ artificial intelligence to create personalized guides and automate triage and referral recommendations. The project aims to...
- The National Institute of Mental Health awarded The General Hospital Corporation (Massachusetts General Hospital) $790,560 under the Mental Health Research Grants program (CFDA 93.242) on April 1, 2026. The award funds development of advanced artificial intelligence models to predict differential antidepressant treatment responses by integrating electronic health records and genomic data. Aim 1 involves building a large language model-based, human-in-the-loop active learning framework to...
- The National Institute of Mental Health awarded the University of Southern California $1.105 million on August 7, 2026, under the Mental Health Research Grants program (CFDA 93.242) to establish a global framework for harmonized functional MRI analysis in psychiatry. The project will harmonize resting-state fMRI datasets across eight psychiatric and neurodevelopmental disorders—schizophrenia, bipolar disorder, post-traumatic stress disorder, major depression disorder, obsessive compulsive...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $722,773 under the Mental Health Research Grants program (CFDA 93.242) on July 15, 2026, to develop explainable artificial intelligence frameworks for predicting depression incidents in people with HIV. The research integrates multimodal data from 3,962 people with HIV across multiple longitudinal studies to elucidate bidirectional associations between HIV, depression, and immune dysregulation. The project...
The National Institute of Mental Health awarded $1,415,720 to Deliberate Solutions Inc. on August 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to advance AI-CLINICAL OUTCOME ASSESSMENT (AI-COA) for Depression toward regulatory qualification and commercial readiness as a drug development tool. The project funds technical development and clinical validation of AI-COA, a multimodal artificial intelligence tool designed to provide objective, standardized assessment of depression severity in clinical trials. The tool addresses limitations of current FDA-approved scales—the Hamilton (HAM-D) and Montgomery and Asberg (MADRS) depression rating scales—which rely on subjective measurement and lack standardization, contributing to high failure rates in Phase 3 depression trials. AI-COA uses computational methods to objectively measure multimodal features of depression severity and has demonstrated high concurrent reliability with HAM-D scores. The FDA has accepted AI-COA into its Innovative Science and Technology Approaches for New Drugs (ISTAND) pilot program, designating it as the first AI and digital health technology and the inaugural neuroscience project in the program. Performance occurs in New York through July 31, 2027. This SBIR Phase II award enables AI-COA to progress toward FDA qualification as a drug development tool, supporting more precise and reliable depression assessments in clinical trials and advancing development of more effective depression treatments.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 8/7/26 |