The National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), awarded a $505,311 Project Grant to Intelligent Imaging Innovations, Inc. (3i) to establish the feasibility of combining advanced optical techniques for large-scale, all-optical electrophysiology. The goal is to develop a commercial instrument that can simultaneously record from thousands of neurons and selectively activate optogenetically-labeled neurons across multiple brain...
The National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), awarded a $449,228 Project Grant to Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for long-term electrophysiological profiling of human brain organoids. The 2-year project, running from March 2025 to February 2027, aims to: 1) develop a biological assay chamber supporting chronic electrophysiology while maintaining organoid health; 2) develop...
The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct emission...
This $299,896 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports the development of a novel modular bioluminescence imaging (BLI) platform called InVivoScan by In Vivo Analytics, Inc. The key products being developed include: A multi-aperture (MA) imaging method featuring a concentric mirror system and stray-light collimator to significantly boost BLI sensitivity and enable multi-view imaging and 3D...
The National Institute of Mental Health (NIMH) awarded a $2,081,204 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Spike Neuro LLC in Ann Arbor, MI. The two-year grant, which commenced on July 18, 2024, aims to develop dual-function carbon-modified silicon microelectrodes for simultaneous neurochemical and electrophysiological measurement in neuroscience research and clinical practice. Specifically, the project will refine carbon deposition processes for silicon electrophysiology...
The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded a $3,045,502 Project Grant to the Regents of the University of Michigan on August 18, 2022 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant funds the development of optical neural motes to enable high-density neural recording through intact dura in nonhuman primates. Specifically, the University of Michigan will design...
Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $187,831 Project Grant (CFDA #93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of California, Davis to develop a miniature two-photon microscope that can simultaneously perform high-resolution calcium imaging and optogenetic manipulation of neural activity in freely-behaving mice. The project will integrate innovative beam forming techniques into a...
The U.S. National Institutes of Health (NIH) awarded a $1,671,116 Cooperative Agreement grant under the Trans-NIH Research Support (CFDA 93.310) program to The Washington University in St. Louis. The 3-year grant, running from September 2023 to August 2026, aims to develop a novel two-component optogenetic system for reversibly controlling the activity of user-defined synaptic connections between specific cell types in the brain. The project will involve engineering light-sensitive G...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $517,546 to Trustees of Dartmouth College to develop a multimodal microelectrode array (MEA) probe capable of parallel electrical recording and sub-second neuromodulator sensing. The key products and services to be delivered under this 5-year award, starting December 13, 2024, include: Optimizing, benchmarking, and validating an integrated MEA...