Designing low-cost, customizable high-density probes for acute and chronic neural recordings in rodents
Ended Project Grant Awarded Last action
- Award ID
- R44MH118155
- Recipient
-
Neural Dynamics Technologies Inc. UEI D4MJFL85BKC8
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $6,087,225
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date
- Originally
- Funding
-
- $5,164,931.00 Federal
- $922,294.00 Non-federal
- Place of performance
- Massachusetts, USA
Award details come from USAspending.gov.
Description
- Abstract
- Understanding how the brain controls behavior requires studying the dynamic activity of different types of neurons in distributed neural circuits in awake behaving animals. Currently, there are few technologies available however that allow researchers to record the activity of hundreds to thousands of neurons at arbitrary depth in the brains of awake, behaving animals. While there has been much recent progress in the development of high-density micro-fabricated silicon probes, current commercially available probes offer little to no customizability to the morphology of different brain regions and different cell types within brain regions. Even more importantly, there are no commercially available solutions of high-density probes with integrated stimulation capabilities enabling causal, closed-loop experimentation. In phase i, we designed and fabricated customizable high-density recording probes for acute head-fixed recordings and streamlined our fabrication strategies. The resulting devices had high yields of functional electrode sites and were successfully used by beta-tester labs to generate data with good signal-to-noise ratios. We furthermore built an online graphical interface where end-users can design their probes and submit their designs for fabrication. In phase II, neural dynamics technologies LLC will develop customizable, high-density probes with integrated closed-loop capabilities that can be chronically implanted for use in animals that are either head-fixed or able to move around freely. The first aim of our phase II proposal is to integrate light delivery and electrical stimulation capabilities onto our probes to enable closed-loop experimentation. The locations for light delivery and electrical stimulation will be customizable so that customers can specify their desired location. The second aim will be to develop a packaging approach that involves building an application specific integrated circuit (asic) and a head-stage that can control all integrated functionalities. The combined packaged device will be small enough to enable chronic experiments in either head- fixed or freely moving animals. The third aim will be to perform both bench-top testing and in vivo animal testing of devices to establish basic functionality and effectiveness of the devices. In summary, NDT will design innovative closed-loop interfaces that will enable causal studies addressing the functional role of different brain regions and neuron types in the brains of both head-fixed and freely moving animals. These types of closed-loop devices may be further evolved into neural implants to treat neurological diseases such as refractory epilepsy, parkinson's and other tremor disorders.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $552,748 | $0 | |
| Amendment | $922,605 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $922,495 | $0 | |
| Amendment | $922,495 | $0 | |
| Amendment | $922,294 | $0 | |
| Original award | $922,294 | $922,294 |
Show all 20
Quick answers
Who received award R44MH118155?
R44MH118155 was awarded to Neural Dynamics Technologies Inc. by National Institute of Mental Health (National Institutes of Health) on September 18, 2018.
How much is award R44MH118155 worth?
$6,087,225 has been obligated on R44MH118155: $5,164,931 in federal funding and $922,294 in non-federal funding.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award