A new and disruptive gene based therapy for atrial fibrillation
Ended Project Grant Awarded Last action
- Award ID
- R44HL154912
- Recipient
-
Inomagen Therapeutics, Inc. UEI G361MCGUDEE5
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,774,483
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date
- Originally
- Funding
-
- $4,311,793.64 Federal
- $462,689.00 Non-federal
- Place of performance
- Ohio, USA
Award details come from USAspending.gov.
Description
- Abstract
- Atrial fibrillation (AF) is the most common heart rhythm disorder that affects >3 million americans and is a major cause of stroke. Since AF is primarily an age-related disease, IT is fast becoming an epidemic in a rapidly aging population. Unfortunately, current therapeutic approaches to AF - both pharmacological and ablation- based - are sub-optimal in patients with persistent AF. This is thought to be because current treatments do not target the fundamental, molecular signaling pathways that cause AF. In this fast-track sbir proposal, rhythm therapeutics, INC (RTI) proposes a radically different approach to AF that targets major molecular mechanisms underlying AF. Using technology licensed from northwestern university, RTI proposes an innovative, gene therapy strategy to target oxidative injury, which is a fundamental, 'upstream' biological mechanism that controls key 'downstream' signaling pathways contributing to electrical and structural remodeling in AF. The technical innovation of RTI's strategy is two-fold: i) use of NOX2 shrna to inhibit NOX2, a major enzymatic source of oxidative injury in the atria and II) a new, trans-venous method of gene delivery that facilitates endocardial gene delivery by using electroporation; for this purpose, we will use a catheter (firmap, abbott-ST. Jude) that is currently approved for electrophysiological mapping of AF. RTI's overarching goal is develop a new, mechanism-guided therapy for AF that has at least 25% greater efficacy than ablation in patients with persistent AF. The goal of this fast-track sbir is to perform investigational new drug (IND) enabling pre-clinical studies with RTI's combination product. The hypothesis underlying this phase II sbir is 'electroporation mediated delivery of NOX2 shrna via a trans-venous route: a) attenuates electrical/structural remodeling in AF in a linear, dose-dependent fashion and b) has a favorable safety profile'. In phase i, specific aim 1, RTI will determine the optimal electroporation parameters for trans- venous atrial gene delivery using the firmap catheter. In phase II, specific aim 1, we will determine the optimal therapeutic dose of NOX2 shrna that prevents atrial fibrosis in a heart failure model of AF. In phase II, specific aim 2, we will determine: a) the optimal therapeutic dose of NOX2 shrna that reverses established electrical remodeling in a rapid atrial pacing model of AF and b) the duration of efficacy of NOX2 shrna in reversing AF in the same AF model. In phase II, specific aim 3, RTI will conduct pivotal toxicology and BIO-distribution studies with its combination product. AF is a $2 billion + market. RTI's therapeutic approach, if successful, is expected to significantly improve upon the success of current pharmacological and ablation strategies for AF, and thereby lead to a paradigm shift in management of AF.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $1,749,913 | $0 | |
| Amendment | -$1 | $0 | |
| Amendment | -$1 | $0 | |
| Amendment | $1,636,504 | $0 | |
| Amendment | $462,689 | $0 | |
| Original award | $462,689 | $462,689 |
Quick answers
Who received award R44HL154912?
R44HL154912 was awarded to Inomagen Therapeutics, Inc. by National Heart Lung and Blood Institute (National Institutes of Health) on May 1, 2021.
How much is award R44HL154912 worth?
$4,774,483 has been obligated on R44HL154912: $4,311,794 in federal funding and $462,689 in non-federal funding.
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