Project Grant R44HL137605

Federal Project Grant Award Summary Advanced Cooling Technologies Inc. (ACT) received a $999,890 federal project grant from the Food and Drug Administration Research program (CFDA 93.103) awarded on September 30, 2025, with completion scheduled for August 31, 2027. The project centers on the development and validation of a novel dry air plasma sterilization system designed to address critical limitations in current endoscope sterilization technologies. The company's innovation delivers three key...

The Department of the Army Medical Command awarded a $1,093,692.71 Project Grant to HMH Hospitals Corporation, doing business as Hackensack University Medical Center, to support a randomized clinical study of convalescent plasma from recovered COVID-19 donors collected through plasmapheresis as treatment for early COVID-19 infection. The study aims to evaluate the safety and efficacy of convalescent plasma as a treatment option for COVID-19 under the Military Medical Research and Development...

The National Science Foundation (NSF) awarded a $878,296 Cooperative Agreement to Surfplasma Inc., a minority-owned small business based in Gainesville, FL, to develop a rapid, low-temperature plasma prototype for disinfecting personal protective equipment (PPE), medical devices, food products and other materials from pathogens like COVID-19. The project, funded under NSF's Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to deliver a market-ready sterilization solution...

Federal Cooperative Agreement Summary The Animal and Plant Health Inspection Service (APHIS) awarded Indiana University a $2,015,659 Cooperative Agreement on February 2, 2026, to develop and validate ultraviolet-C (UVC) light technologies as biosecurity interventions against highly pathogenic avian influenza (HPAI) in commercial egg-laying operations. Under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025), the project addresses three primary HPAI transmission...

This $255,982 National Science Foundation project grant supports the development of sustainable, cost-effective viral clearance membranes by Filtravate, Inc. to enable efficient monoclonal antibody processing. The NSF Technology, Innovation, and Partnerships program seeks technologies leading to breakthrough solutions for national challenges. Specifically, Filtravate will develop a virus filtration membrane using a synthesis process that is more sustainable and affordable than conventional...

The National Science Foundation awarded a $275,000 STTR Phase I grant to Inaedis, Inc. to develop an innovative method for the thermal stabilization of biopharmaceutical formulations. The project aims to establish a rapid room-temperature aerosol dehydration (RTAD) process that improves the stability of biologics, vaccines, and other pharmaceuticals, circumventing the need for a cold chain supply. This technology seeks to serve international markets by allowing the pharmaceutical industry to...

The University of Cincinnati will evaluate a novel filter strategy to reduce donated whole blood antibody titers under a $351,563 cooperative agreement from the Department of the Air Force. The award is part of the Air Force's Defense Research Sciences Program (CFDA 12.800), which aims to maintain technological superiority in scientific areas relevant to Air Force needs and prevent technological surprise. Under the December 21, 2022 award, set to run through September 20, 2024, the University...

Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Columbia University's Health Sciences Division a $1.56 million Project Grant (CFDA 93.837—Cardiovascular Diseases Research) on July 20, 2025, for the Functional Coagulation and Hemostasis After Intracerebral Hemorrhage (FIGHT-ICH) study, with an ultimate completion date of April 30, 2030. This clinical research initiative addresses critical gaps in identifying coagulopathy (blood clotting dysfunction) in...

Federal Project Grant Award Summary Cisterna Biologics, Inc. received a $349,746 project grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective August 1, 2025, through July 31, 2027, to develop and validate an innovative mRNA purification platform. Under this Phase I Small Business Innovation Research (SBIR) grant, Cisterna will demonstrate the efficacy of its technology in eliminating three primary mRNA contaminants—double-stranded RNA...

This $902,504 cooperative agreement from the National Science Foundation Division of Industrial Innovation under the Engineering program (CFDA 47.041) supports the development of a scalable downstream purification process for gene therapy vectors by Isolere Bio, Inc. of Durham, North Carolina. The non-chromatographic method seeks to address current inefficiencies that lead to single digit yields by utilizing a polypeptide-based reagent combining affinity capture with phase separation and...