Project Grant R44HL137540

This $977,998.39 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund a clinical trial to evaluate the use of venous ethanol ablation (VE) in combination with radiofrequency (RF) catheter ablation for treating ischemic ventricular tachycardia (VT). The trial, titled "Venous Ethanol for Left Ventricular Ischemic Ventricular Tachycardia (VELVET)", will compare the efficacy and safety of...

Venarum Medical LLC received a $255,619 Project Grant award from the National Science Foundation on August 15, 2021 to support research and development activities concluding on May 31, 2022. The funding was provided through the NSF's Engineering program (CFDA #47.041), which aims to improve quality of life and economic strength through engineering innovation and excellence. Specifically, the grant supports Venarum Medical's "SBIR PHASE I: INTEGRATED MANUFACTURING OF ARTIFICIAL VALVES FOR...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $226,192 to Endonavis LLC, a small disadvantaged business located in Louisville, Kentucky. The grant supports the development of a novel over-the-scope platform for controlling variceal bleeding, a major complication of cirrhosis. The project aims to design a therapeutic...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $299,518 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to V-Flow Medical Inc. to develop a novel diagnostic catheter and modular stent system to treat pelvic venous insufficiency (PVI), a primary cause of chronic pelvic pain (CPP) in women. The project will utilize an ovine model to evaluate the safety and efficacy of V-Flow's catheter and stent system in improving clinical outcomes...

Endoshape, Inc. was awarded a $370,938 project grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to develop radiopaque shape memory polymers for neurovascular embolotherapy applications. The Cardiovascular Diseases Research program aims to support heart and vascular research, including through competitive research training grants. Under this award, Endoshape will develop new radiopaque shape memory polymer materials incorporated into embolic coils....

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $1,013,000 Project Grant to Endolynx Inc. to develop an Optical Sensor-Enabled Endotracheal Tube (OS-ETT). The goal of this SBIR Phase I project is to demonstrate the feasibility of the OS-ETT, which aims to reduce the risk and incidence of esophageal intubation and unintended extubation during the over 30 million intubations performed annually in the U.S. The OS-ETT...

Corveus Medical, Inc. was awarded a $255,841 Project Grant from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an extravascular bipolar catheter for targeted nerve ablation with minimal collateral damage to surrounding tissues. The grant aims to support the design and prototyping of a minimally invasive, catheter-delivered venous procedure for performing extravascular greater splanchnic nerve ablation. The proposed catheter...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant of $275,000 awarded to Xtract Medical Inc. aims to develop and demonstrate the feasibility of a novel catheter-based system for improved removal of blood clots during mechanical thrombectomy procedures to treat venous thromboembolism (VTE). The proposed system is designed to effectively remove large blood clots while minimizing damage to blood vessels and reducing complications such as...

This Project Grant award from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,082,412 to the University of Pittsburgh to optimize and prepare for the manufacturing and regulatory submission of an immunoregulatory tissue-engineered vascular graft (TEVG) device. The key objectives are to: Evaluate the TEVG constructs in vitro using clinically-relevant measures, 2) Validate the performance of scaled-up, human-sized...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $704,672 to Flowpoint Medical Inc. to develop an implantable self-sealing needle guide system to improve vascular access and safety for hemodialysis patients. The award will fund the refinement of the device's manufacturability and operational parameters, as well as a large animal...