Project Grant 2233665
- This $1,199,991 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program aims to develop novel technologies for real-time assessment of blood clot properties to improve stroke treatment. The key products and services under this grant include: Integration of a sub-millimeter Raman fiber probe into a catheter for intravascular, in-vivo measurement of clot chemical composition. Training of a convolutional neural network to...
- This $256,000 National Science Foundation project grant supports the development of an automated chest tube to prevent clotting. Circulatech LLC will design and prototype a novel chest tube that proactively manages fluid flow within the catheter lumen to flush and drain the tube, reducing blood clot formation. Through a process called "dilutional coagulopathy," the tube will use sterile saline or anticoagulants to reduce thrombosis in the drainage space rather than relying on...
- This $240,412 Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) supports collaborative research at East Carolina University (ECU) to investigate how tension affects the digestion of blood clots. The research aims to test hypotheses about how inherent and applied tension on fibrin fibers impact the fibrinolysis process, which is essential for the proper dissolution of blood clots to prevent risks like strokes and heart attacks. The...
- This Project Grant award of $506,803, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), will fund research by the Research Foundation for the State University of New York (RF SUNY) to develop advanced multiscale modeling capabilities for predicting thrombus (clot) formation and its response to external loads. The goal is to create computational tools that can better forecast clot growth and rupture under varying blood flow conditions, such as pulsatile...
- This National Science Foundation (NSF) Project Grant award under CFDA 47.041 (Engineering) supports the development of a new computational model to predict the complex interactions between ventricular assist devices (VADs) and the beating native heart. The goal is to create a "digital twin" of an experimental mock circulatory loop used for testing VAD safety and efficacy. This $195,291 award, effective August 1, 2024 through July 31, 2026, will result in a lumped parameter model that...
- This federal Project Grant award from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation (CFDA 47.041 - Engineering) provides $500,000 in funding to North Carolina State University to conduct fundamental research aimed at reducing blood clotting in medical devices. The key products and services to be delivered under this award include: 1) molecular dynamics simulations and interfacial spectroscopy to understand the role of hydration layers in preventing...
- This National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I project under CFDA 47.084 - NSF Technology, Innovation, and Partnerships provides $275,000 to Medfree Inc., a minority-owned small business, to develop a novel, transcatheter device and procedure for the minimally invasive surgical revision and repair of the tricuspid valve. The project aims to address the significant unmet need for percutaneous treatment options for the over 1.6 million U.S. patients...
- Corveus Medical, Inc. was awarded a $255,841 Project Grant from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an extravascular bipolar catheter for targeted nerve ablation with minimal collateral damage to surrounding tissues. The grant aims to support the design and prototyping of a minimally invasive, catheter-delivered venous procedure for performing extravascular greater splanchnic nerve ablation. The proposed catheter...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant awarded $274,440 to Vine Medical Inc., a for-profit manufacturing company, to develop a proof-of-concept for a self-deploying endotracheal intubation device. The proposed soft robotics system aims to achieve over a 90% first-pass intubation success rate, which would improve patient outcomes and reduce complications during emergency airway management procedures. The device is designed to...
- This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $274,811 to Anova Biomedical, Inc. to develop 3D printed personalized vascular grafts using novel elastomeric resins. The key objectives are to: 1) develop and characterize the novel 3D printing resin for producing personalized, elastic, and bioresorbable vascular grafts; 2) demonstrate the ability to 3D print vascular prosthetics using patient CT...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant of $275,000 awarded to Xtract Medical Inc. aims to develop and demonstrate the feasibility of a novel catheter-based system for improved removal of blood clots during mechanical thrombectomy procedures to treat venous thromboembolism (VTE). The proposed system is designed to effectively remove large blood clots while minimizing damage to blood vessels and reducing complications such as post-thrombotic syndrome. The project scope includes developing a first-generation prototype, and validating its performance across a range of clot sizes, shapes, and properties using preclinical testing. This effort seeks to improve the clinical effectiveness of mechanical thrombectomy and reduce long-term patient care costs associated with VTE, which affects over 1 million Americans annually at a cost of $10 billion in direct medical expenses.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $275.0k | 7/17/23 |