Project Grant R44GM161156
- This $316,825 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the field of native mass spectrometry (MS) analysis. The research project will develop an innovative intact mass deconvolution method to significantly improve the speed, accuracy, and user-friendliness of proteins and nucleic acid molecular weight determination using MS. The key objectives are to implement...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
- The federal Project Grant award of $350,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development and demonstration of a novel enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. This innovative platform leverages enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $423,330 project grant to the University of Kansas Center for Research Inc. The grant, effective August 1, 2025 through June 30, 2030, focuses on developing innovative technologies to enable new discoveries in biomedical research using mass spectrometry. The key products to be delivered include: A completely noninvasive, non-painful sampling method...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,243 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. on September 12, 2025. The grant supports the development of an innovative "Spotlight-Omics" workflow that can cost-effectively isolate disease-relevant spatiotemporal phenotypes from live cell cultures for subsequent omics analysis. This workflow aims to address a critical limitation of current...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 Biomedical Research and Research Training provides $350,000 to Fluidispec LLC to develop a new microfluidic/nanofluidic sample preparation platform. The goal is to improve single-cell and low-input proteomics analysis by enabling efficient extraction of proteins from cells, removal of contaminants, and improved protein denaturation. This platform is expected to enhance...
- This federal Project Grant award in the amount of $271,495.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and evaluation of a time-of-flight (TOF) mass spectrometer system with matrix-assisted laser desorption/ionization (MALDI) for fast analysis of antibodies and related macromolecular immune complexes. The goal is to utilize a novel high-temperature superconducting...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and commercialization of Newomics Inc.'s UNIESI system with M3 emitters and MEA chips as an integrated imaging-mass spectrometry front-end platform for native spray mass spectrometry. The $1,000,000 award will be used to validate the platform's performance for native MS studies of biomolecular interactions, focusing on conformational changes and ligand binding under native conditions. Once commercialized, the UNIESI platform is expected to facilitate high-throughput and high-sensitivity top-down proteomics and native mass spectrometry, contributing to precision medicine through the discovery of new drugs and druggable targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/12/25 |