Project Grant R44GM159549
- This $256,000 National Science Foundation SBIR Phase I Project Grant to Airomatix, Inc. supports the development of a portable oxygen concentrator capable of producing breathable oxygen at higher flow rates than current models. The concentrator utilizes a novel photocatalytic reaction to separate oxygen from ambient air and store it in a chemical solution. It will then release oxygen on demand through a temperature-controlled reaction. During the one-year period of performance ending March 2023,...
- The federal Project Grant award of $731,827 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting research conducted by the J. David Gladstone Institutes in San Francisco, CA to investigate the mechanisms of oxygen toxicity. The key objectives include: 1) testing whether specific molecular pathways (diphthamide synthesis, de novo purine synthesis, and mitochondrial electron transport chain) are necessary and sufficient for impaired cell...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $421,600 to The Morgridge Institute for Research, Inc. to understand how metabolic conditions influence the behavior of human cells. The key products and services to be delivered under this 5-year award include: Elucidating genetic and environmental contributions to human cell fitness and growth, leveraging innovative tools such as a...
- The federal Project Grant award of $283,805 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a novel cell-free, high-throughput platform to expedite the engineering of enzymes for biocatalytic "BioClick" reactions. The project, undertaken by Invizyne Technologies, Inc., a small disadvantaged business in Monrovia, CA, focuses on establishing an efficient cell-free protein...
- The National Institute of General Medical Sciences (NIGMS) awarded a $324,239 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Ora Biomedical, Inc., a biotechnology company in Seattle, WA. The purpose of this Phase I Small Business Innovation Research (SBIR) grant is to develop "ELEGANTRY", a software and hardware infrastructure to improve rigor and reproducibility in invertebrate research using the model organism Caenorhabditis elegans (C....
- This Project Grant award, valued at $498,991.40, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Arkansas, Fayetteville. The goal is to engineer microphysiological systems with tight oxygen control to investigate the molecular pathways activated in oxygen gradients and the resulting effects on cardiomyocyte function, in order to obtain a comprehensive understanding of the cardiac response to hypoxic...
- The National Heart, Lung, and Blood Institute (NHLBI), through its Cardiovascular Diseases Research program (CFDA 93.837), awarded Pranions, Inc. a $2,426,364 project grant to develop a next-generation, high-flow portable oxygen concentrator (POC) for long-term oxygen therapy (LTOT). The proposed POC device aims to address shortcomings of existing commercial POC options, such as inadequate oxygen flow, excess weight, short battery life, and noisy operation, by leveraging a novel hybrid...
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
- The National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training program (CFDA 93.859), awarded a $963,619 Project Grant to Osem Fluidics Inc. on January 1, 2025. The award supports the development of 3D-printed microfluidic channel architectures to precisely control the structure and properties of lipid nanoparticles (LNPs) for enhanced nucleic acid delivery. Key objectives include designing and testing 3D channel designs to manipulate flow...
- This $761,271.00 Project Grant was awarded on July 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois. The grant supports fundamental scientific research to detail the threats that oxygen poses, the defenses that organisms have evolved, and the situations in which oxidative stress exerts a strong impact upon microbial fate. The research aims to identify the particular...
This Project Grant award of $229,072 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and validation of Oxylo, Inc.'s innovative "Hypoxycaps" technology. The Hypoxycaps prototype enables rapid, precise, and scalable manipulation of oxygen levels in laboratory and clinical settings, addressing a key gap in existing oxygen control methods. The funding will be used to refine production processes, enhance reproducibility and longevity of the Hypoxycaps, and demonstrate their versatility in various research models, including cancer drug development, cardiac modeling, and live cell tracking. This fast-track proposal aims to revolutionize oxygen control and support advancements in the fundamental understanding of oxygen-dependent biological processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $229.1k | 7/31/25 |